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Kinases

  • 3PO | 6-Phosphofructo-2-kinase (PFKFB3) inhibitor

    CAS:
    18550-98-6
    Catalog Number:
    10-4609
    Activity:
    6-Phosphofructo-2-kinase (PFKFB3) inhibitor
    Chemical Name:
    (2E)-3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
    Molecular Weight:
    210.23
    Molecular Formula:
    C13H10N2O
    Solubility:
    Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    Pale yellow solid
    Purity:
    99% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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  • Abemaciclib | Potent and selective CDK 4/6 inhibitor

    CAS:
    1231930-82-7
    Catalog Number:
    10-4833
    Activity:
    Potent and selective CDK 4/6 inhibitor
    Chemical Name:
    N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridine-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine methanesulfonic acid salt
    Alternate Name:
    LY2835219 mesylate
    Molecular Weight:
    602.70
    Molecular Formula:
    C27H32F2N8 ∙ CH3SO3H
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
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  • ABT-869 | Dual VEGFR and PDGFR kinase inhibitor

    ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 […]

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  • Acalabrutinib | Highly selective BTK inhibitor

    CAS:
    1420477-60-6
    Catalog Number:
    10-4806
    Alternate Name:
    ACP-196
    Activity:
    Highly selective BTK inhibitor
    Chemical Name:
    4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
    Molecular Weight:
    465.52
    Molecular Formula:
    C26H23N7O2
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)

     

    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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  • Adavosertib | Wee1 kinase inhibitor

    CAS:
    955365-80-7
    Catalog Number:
    10-4823
    Activity:
    Wee1 kinase inhibitor
    Chemical Names:
    1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
    Alternate Name:
    MK-1775; AZD1775
    Molecular Weight:
    500.61
    Molecular Formula:
    C27H32N8O2
    Solubility:
    Soluble in DMSO (70 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
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Plymouth Meeting, PA USA
1-855-FOCUS21

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