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Kinases

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  • Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

  • Focus Biomolecules cell signaling supplier, chemical structure of Afatinib | EGFR, HER2 inhibitor | CAS 850140-72-6
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG 1478 | EGFR kinase inhibitor | CAS 175178-82-2
    $50.00
    AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines1,2. AG-1478 reduces pulmonary fibrosis in a rat model3. Cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of AG-1296 | PDGFR kinase inhibitor | CAS 146535-11-7
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • Focus Biomolecules supplier, chemical structure of AG-1517 HCl | Tyrosine kinase inhibitor | CAS 153436-54-5
    $70.00
    AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG-490 | JAK-2 inhibitor | CAS 133550-30-8
    $50.00
    AG-490 (133550-30-8) is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure AG-879 | NGFR kinase inhibitor | CAS 148741-30-4
    $70.00
    AG-879 (148741-30-4) inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC50 = 10 μM). No inhibition of EGF, or PDGF receptor phosphorylation is...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Alisertib | Aurora A inhibitor | CAS 1028486-01-2
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Axitinib | VEGFR kinase inhibitor | CAS 319460-85-0
    $40.00
    Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AZD6244 | ERK inhibitor | CAS 606143-53-6
    $75.00
    AZD6244 (606143-53-6) is a potent, selective, and non-ATP competitive inhibitor of MEK1/2 (IC50 MEK1 = 14 nM) and ERK 1/2 phosphorylation (IC50 = 10 nM).1,2 AZD6244 is in clinical trials for treating various cancers.3-7...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AZD8055 | mTOR kinase inhibitor | CAS 1009298-09-2
    $45.00
    AZD8055 (1009298-09-2) is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM).1,2  mTOR acts as a nutrient/energy/redox sensor and a controller of protein...

  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    $90.00
    BI-D1870 (501437-28-1) is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental...

  • Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

  • Focus Biomolecules cell signaling supplier, chemical structure of Cabozantinib | MET & VEGFR2 inhibitor | CAS 849217-68-1
    $70.00
    Cabozantinib (849217-68-1) is a novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CID-2011756 | PKD inhibitor | CAS 638156-11-3
    $75.00
    CID-2011756 (638156-11-3) is a potent and selective ATP-competitive inhibitor of protein kinase D (PKD). IC50=3.2, 0.6 and 0.7 μM for PKD1, 2 and 3 respectively. Inhibits phorbol ester-induced PKD activation in LNCaP...

  • Focus Biomolecules cell signaling supplier, chemical structure of Crizotinib | c-MET and ALK inhibitor | CAS 877399-52-5
    $80.00
    Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50's=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of...

  • Focus Biomolecules cell signaling supplier, chemical structure of CUDC-101 | Dual HDAC & EGFR inhibitor | CAS 1012054-59-9
    $70.00
    CUDC-101 (CAS 1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,  IC50 = 4.4, 2.4 and 15.7 nM respectively.1 It not...

  • Focus Biomolecules reagent supplier, chemical structure CZC-8004 | Multi-kinase inhibitor; affinity ligand | CAS 916603-07-1
    $90.00
    CZC-8004 (916603-07-1) is a pan-specific kinase inhibitor. May be coupled to sepharose via its amino-side chain for affinity chromatography applications1. References/Citations1) Klutchko et al. (1998), 2-Substituted...

  • Focus Biomolecules cell signaling supplier, chemical structure of Dabrafenib | B-Raf mutant inhibitor | CAS 1195765-45-7
    $34.00
    Dabrafenib (1195765-45-7) is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical...

  • Focus Biomolecules supplier, chemical structure of Dasatinib | Src and Bcr/Abl inhibitor | CAS 302962-49-8
    $50.00
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

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