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Metastasis

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  • Focus Biomolecules reagent supplier, chemical structure of 1,4-DPCA | Prolyl hydroxylase inhibitor | CAS 331830-20-7
    $60.00
    1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing...

  • Alpha-Mangostin | STING agonist (human)
    $50.00
    α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Carnosic acid | Antioxidant | CAS 3650-09-7
    $40.00
    Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Cilastatin Na | Protease inhibitor | CAS 81129-83-1
    $60.00
    Cilastatin Na (81129-83-1) is a dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1  Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CL-82198 | MMP-13 inhibitor | CAS 307002-71-7
    $50.00
    CL-82198 (307002-71-7) is a selective inhibitor of MMP-13 (IC50 = 10 μM). It displayed no activity against MMP-1, MMP-9 or TACE. References/Citations1) Chen, et al. (2000), Structure-based design of a novel, potent, and...

  • Focus Biomolecules supplier, chemical structure of Dasatinib | Src and Bcr/Abl inhibitor | CAS 302962-49-8
    $50.00
    Dasatinib (302962-49-8) inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively).1,2 Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of FH-535 | Wnt/beta-cantenin inhibitor | CAS 108409-83-2
    $50.00
    FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1...

  • Focus Biomolecules cell signaling supplier, chemical structure of FPS-ZM1 | RAGE receptor antagonist | CAS 945714-67-0
    $60.00
    FPS-ZM1 (945714-67-0) is a high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (IC50 = 0.6 μM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple...

  • Maraviroc | CCR5 Antagonist
    $59.00
    Maraviroc (376348-65-1) is a potent and selective CCR5 antagonist with potent anti-HIV activity. It prevents HIV-1 gp120 binding to CCR5 preventing cell-cell fusion. Maraviroc inhibited MIP-1a (IC50 = 3.3 nM), MIP-1b (IC50 =...

  • Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor
    $58.00
    Napabucasin (83280-65-3) inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective...

  • NSC-47924 | PHLP phosphatase inhibitor / Laminin inhibitor
    $60.00
    A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure P0180 | PRL-3 phosphatase inhibitor | CAS 893449-38-2
    $60.00
    P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1  Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes...

  • Focus Biomolecules supplier, chemical structure Zoledronic acid | Antiproliferative and apopototic effects | CAS 118072-93-8
    $45.00
    Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast...

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