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Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor

CAS:
83280-65-3
Catalog Number:
10-3442
Activity:
STAT3 inhibitor / Cancer cell stemness inhibitor
Chemical Name:
2-Acetylnsphtho[2,3-b]furan-4,9-dione
Alternate Names:
BBI608
Molecular Weight:
240.21
Molecular Formula:
C14H8O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Napabucasin (83280-65-3) inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models.2 Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer.2,3 Overcomes cisplatin resistance in non-small cell lung cancer.4

References/Citations:

1) Li et al. (2015), Suppression of cancer relapse and metastasis by inhibiting cancer stemness; Proc. Natl. Acad. Sci. USA, 112 1839
2) Hubbard and Grothey (2017), Napabucasin: an Update on the First-in-Class Cancer Stemness Inhibitor; Drugs, 77 1091
3) Zhang et al. (2016), Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin; Cancer Med., 5 1251
4) MacDonagh et al. (2018), BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC; Cancer Lett., 428 117

Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor is also available in the Cellular Metabolism Library.
CAS:
83280-65-3
Catalog Number:
10-3442
Activity:
STAT3 inhibitor / Cancer cell stemness inhibitor
Chemical Name:
2-Acetylnsphtho[2,3-b]furan-4,9-dione
Alternate Names:
BBI608
Molecular Weight:
240.21
Molecular Formula:
C14H8O4
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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