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  • Amifostine | Cellular protectant
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants...

  • Batimastat | 130370-60-4 | Structure | Supplier
    Batimastat (130370-60-4) is a potent, broad spectrum MMP inhibitor (IC50 =3, 4, 4, 6 and 20 nM for MMPs -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human...

  • C-DIM 12 | Nurr1 activator; NFkB inhibitor
    C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, structure of Cantharidin | Phosphatase PP2A inhibitor | CAS 56-25-7
    Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via...

  • Focus Biomolecules cell signaling reagent supplier, structure Cyclopamine | Inhibits hedgehog signaling | CAS 4449-51-8
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • DMAPT | NFkB inhibitor
    DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DU-14 | Sulfatase inhibitor | CAS 186303-55-9
    DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats1. Inhibits proliferation of human MCF-7 breast cancer cells2. References/Citations1) Johnson et al. (2000), The...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Everolimus | mTOR inhibitor | CAS 159351-69-6
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • FAK inhibitor 14 | FAK inhibitor
    FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397...

  • Focus Biomolecules cell signaling reagent supplier, structure of FH-535 | Wnt/beta-cantenin inhibitor | CAS 108409-83-2
    FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1...

  • Genistein | Tyrosine kinase inhibitor
    Genistein (446-72-0) is a naturally occurring flavonoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase.1,2 Phytoestrogen3 and agonist at GPR304...

  • Herboxidiene | 142861-00-5 | Structure | Supplier
    Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit...

  • Ibandronate | Farnesyl pyrophosphatase synthase inhibitor / osteoporosis drug
    Ibandronate (138926-19-9) is a clinically useful drug for the prevention and treatment of osteoporosis and skeletal fractures in patients with cancer.  It is a potent inhibitor of farnesyl pyrophosphate synthase (IC50 =...

  • KC7F2 | HIF-1alpha inhibitor
    KC7F2 is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of...

  • Matrine | Induces RIP3-dependent necroptosis
    Matrine (519-02-8) is a natural product found in the plant Sophora flavescens.  It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic...

  • Focus Biomolecules cell signaling tech supplier, structure of MLN4924 | NEDD8 activating enzyme inhibitor | CAS 905579-51-3
    MLN4924 (905579-51-3) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. Disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Supresses the growth of tumor...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of NSC-66811 | p53/mdm2 inhibitor | CAS 6964-62-1
    NSC-66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable...

  • Focus Biomolecules supplier, chemical structure of Phorbol 12-myristate-13-acetate | PKC activator | CAS 16561-29-8
    Phorbol 12-myristate-13-acetate (16561-29-8) activates protein kinase C (10-100 ng/ml)1. May display PKC-independent effects in various cell types2. Warning: Phorbol 12-myristate-13-acetate is a skin irritant. Avoid contact...

  • Prostratin | Promotes neuro-regeneration
    Prostratin (60857-08-1) is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrata.1,2 Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents.3...

  • Rocaglamide | TNFalpha inhibitor
    Rocaglamide (84573-16-0) is a potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200nM.1  It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and...

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