Cancer
Angiogenesis Autophagy Carcinogenesis Cell Cycle Cellular Stress Chemotherapeutics Cytoskeleton DNA Damage Drug resistance Epigenetics Growth factors Immunoconjugates Immunology Kinases Metabolism Metastasis Other Cancer p53 Programmed cell death Stem Cells Ubiquitin proteasome Inflammation
Showing 25–36 of 501 results
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New Products
ABT-737 | Senolytic Bcl2 inhibitor
ABT-737 (852808-04-9) is an inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regress...$80.00 – $245.00 Select options -
New Products
Acalabrutinib | Highly selective BTK inhibitor
Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved t...$45.00 – $145.00 Select options -
Cancer
Aclacinomycin A HCl | Proteasome inhibitor
Aclacinomycin A HCl (75443-99-1) is a specific inhibitor of the 20S proteasome chymotrypsin-like activity.1 Inhibition of Brg1 proteasomal degradat...$70.00 – $290.00 Select options -
Cancer
Actinomycin D | Transcription inhibitor
Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of R...$50.00 – $200.00 Select options -
Apoptosis
Adapalene | Retinoid RARbeta, gamma agonist
Adapalene (106685-40-9) is a stable analog of retinoic acid that acts as a selective agonist for RARβ and RARγ. Adapalene also inhibits proliferati...$30.00 – $50.00 Select options -
New Products
Adavosertib | Wee1 kinase inhibitor
Adavosertib (955365-80-7) inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage ch...$45.00 – $155.00 Select options -
New Products
AE 51310 | OPN4/melanopsin antagonist
AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil func...$50.00 – $195.00 Select options -
Approved Drugs
Afatinib | EGFR and HER2 inhibitor
Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly ...$55.00 – $140.00 Select options -
Cancer
AG 1478 | EGFR kinase inhibitor
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer ...$50.00 – $150.00 Select options -
Apoptosis
AG-1296 | PDGFR kinase inhibitor
AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung...$60.00 – $260.00 Select options -
Cancer
AG-1517 HCl | EGFR kinase inhibitor
AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits ...$70.00 – $290.00 Select options -
Cancer
AG-490 | JAK2 inhibitor
AG-490 (133550-30-8) is a potent inhibitor of the JAK2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2...$50.00 – $150.00 Select options
