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PD-1/PD-L1 Inhibitor 1

CAS:
1675201-83-8
Catalog Number:
10-4901
Activity:
PD-1/PD-L1 inhibitor
Chemical Name:
(2S)-1-[[2,6-Dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]pipieridine-2-carboxylic acid
Alternate Name:
BMS-3
Molecular Weight:
475.59
Molecular Formula:
C29H33N2O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1

References/Citations:

1) Chupak et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820

PD-1/PD-L1 Inhibitor 1 is also available in the Cellular Metabolism Library.
CAS:
1675201-83-8
Catalog Number:
10-4901
Activity:
PD-1/PD-L1 inhibitor
Chemical Name:
(2S)-1-[[2,6-Dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]pipieridine-2-carboxylic acid
Alternate Name:
BMS-3
Molecular Weight:
475.59
Molecular Formula:
C29H33N2O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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