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Ubiquitin Proteasome

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  • Focus Biomolecules cell signaling reagent supplier, structure of Aclacinomycin A | Proteasome inhibitor | CAS 57576-44-0
    $75.00
    Aclacinomycin A HCl (75443-99-1) is a specific inhibitor of the 20S proteasome chymotrypsin-like activity.1 Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 μM in ILU-18 cells ) the removal of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of b-AP15 | DUB inhibitor | CAS 1009817-63-3
    $60.00
    b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of...

  • Focus Biomolecules supplier, chemical structure of Bortezomib | Proteasome inhibitor | CAS 179324-69-7
    $50.00
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Focus Biomolecules supplier, chemical structure of Carfilzomib | Proteasome inhibitor | CAS 868540-17-4
    $50.00
    Carfilzomib (868540-17-4) is a potent and irreversible proteasome inhibitor.1 Synthetic analog of the microbial product epoxomcin.2 Compared to bortezomib it displays equal potency but greater selectivity for the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celastrol | Proteasome inhibitor | CAS 34157-83-0
    $50.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • Focus Biomolecules supplier, chemical structure of Epoxomicin | Irreversible 20S proteasome inhibitor | CAS 134381-21-8
    $145.00
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

  • Lenalidomide | Immunomodulator
    $35.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MDBN | p97 inhibitor | CAS 1485-00-3
    $40.00
    MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable References/Citations1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that...

  • Focus Biomolecules cell signaling tech supplier, structure of MLN4924 | NEDD8 activating enzyme inhibitor | CAS 905579-51-3
    $40.00
    MLN4924 (905579-51-3) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. Disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Supresses the growth of tumor...

  • NSC-697923 | 343351-67-7 | Structure | Supplier
    $50.00
    NSC-69723 (343351-67-7) is a selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B...

  • P22077 | Selective USP7 inhibitor
    $65.00
    P22077 (1247819-59-5) is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of P5091 | DUB USP7 inhibitor | CAS 882257-11-6
    $60.00
    P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM)1,2. Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance1. P5091 displays antiangiogenic...

  • Piperlongumine | Glutathione sponge / Increases ROS levels
    $30.00
    Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PR-619 | DUB inhibitor | CAS 2645-32-1
    $48.00
    PR-619 (2645-32-1) is a nonselective, reversible inhibitor of cysteine-reactive deubiquitinating enzymes (DUBs; 5-20 μM)1. PR-619 is highly useful for preserving ubiquitinated proteins during cell lysis. DUBs become...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Pyr41 | E1 UAE inhibitor | CAS 418805-02-4
    $50.00
    Pyr41 (418805-02-4) inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 μM) with little or no activity against E2 or E3. Cell permeable References/Citations1) Yang et al. (2007), Inhibitors of...

  • Focus Biomolecules supplier, structure of Spautin-1 | Inhibits autophagy by inhibiting USP 10 & 13 | CAS 1262888-28-7
    $70.00
    Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1...

  • Focus Biomolecules cell signaling reagent supplier, structure of Thalidomide | E3 UB ligase inhibitor | CAS 50-35-1
    $50.00
    Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of WP-1130 | DUB inhibitor | CAS 856243-80-6
    $50.00
    WP-1130 (856243-80-6) is a novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis.1 Blocks Jak2 signaling via Jak2...

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