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Zebularine | DNA methylation inhibitor

CAS:
3690-10-6
Catalog Number:
10-2432
Activity:
DNA methylation inhibitor
Alternate Names:
NSC 309132
Chemical Name:
1H-β-D-Ribofuranosyl-2-pyrimidinone
Molecular Weight:
228.21
Molecular Formula:
C9H12N2O5q
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine deaminase (Ki ~ 2 μM and; induces differentiation of mesenchymal stem cells into cardiomyocytes.

Zebularine | DNA methylation inhibitor is also available in the Cellular Metabolism Library.
CAS:
3690-10-6
Catalog Number:
10-2432
Activity:
DNA methylation inhibitor
Alternate Names:
NSC 309132
Chemical Name:
1H-β-D-Ribofuranosyl-2-pyrimidinone
Molecular Weight:
228.21
Molecular Formula:
C9H12N2O5q
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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