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PhysioProcesses

Cardiovascular

Cardiovascular disease encompasses a broad range of pathologies including narrow or blocked blood vessels, heart muscle and valve failure, heart arrhythmias, and hypertension.

Angiogenesis

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and

Arrhythmia

ML277 | Potent Kv7.1 activator

ML277 (1401242-74-7) is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+

Norfluoxetine HCl | Fluoxetine Metabolite

CAS:
57226-68-3
Catalog Number:
10-2671
Alternate Name:
Desmethylfluoxetine
Activity:
Fluoxetine metabolite
Chemical Name:
3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride (racemic)
Molecular Weight:
331.76
Molecular Formula:
C16H16F3NO HCl
Solubility:
Soluble in DMSO ( up to at least 25 mg/ml)
Physical Properties:
Beige waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Disopyramide | Antiarrhythmic

CAS:
3737-09-5
Catalog Number:
10-4302
Activity:
Antiarrhythmic
Chemical Name:
4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide
Molecular Weight:
339.48
Molecular Formula:
C21H29N3O
Solubility:
Soluble in DMSO (25 mg/ml) and Ethanol (>35 mg/mL)
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Atherosclerosis

Cardiac Stem Cells

PTC-209 | BMI-1 inhibitor

CAS:
315704-66-6
Catalog Number:
10-4022
Activity:
BMI-1 inhibitor
Chemical Names:
N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine
Molecular Weight:
495.19
Molecular Formula:
C17H13Br2N5OS
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation

CAS:
10045-45-1
Catalog Number:
10-3204
Activity:
K+ channel activator; Promotes cardiomyocyte differentiation
Chemical Name:
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
Alternate Names:
1-Ethylbenzimidazolinone
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Crystalline solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AS-8351 | KDM5B histone demethylase inhibitor

CAS:
796-42-9
Catalog Number:
10-1597
Activity:
KDM5B histone demethylase inhibitor
Chemical Names:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Molecular Weight:
291.30
Molecular Formula:
C17H13N3O2
Solubility:
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cardioprotection

Gue1654 | OXE-R biased antagonist

Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not

Heart Failure

AZD5904 | Myeloperoxidase inhibitor

CAS:
618913-30-7
Catalog Number:
10-4058
Activity:
Myeloperoxidase inhibitor
Chemical Names:
3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one
Alternate Name:
TX4
Molecular Weight:
252.29
Molecular Formula:
C10H12N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

BI 749327 | Selective TRPC6 blocker

CAS:
2361241-23-6
Catalog Number:
10-4318
Activity:
Selective TRPC6 blocker
Chemical Names:
[4-(6-Aminopyridazin-3-yl)piperidin-1-yl]-[4-[4-(trifluoromethyl)phenoxy]phenyl]methanone
Molecular Weight:
442.44
Molecular Formula:
C23H21F3N4O2
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Metolazone | UPR activator and longevity inducer

CAS:
17560-51-9
Catalog Number:
10-5417
Activity:
UPR activator and longevity inducer
Chemical Name:

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

Molecular Weight:
365.83
Molecular Formula:
C16H16ClN3O3S
Solubility:
Soluble in DMSO (up to 36 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Shipping Code:
RT

Hypertension

TPPU | Soluble epoxide hydrolase inhibitor

TPPU (1222780-33-7) is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier

GFB-8438 | Selective TRPC5 inhibitor

GFB-8438 (2304549-73-1) is a potent (IC50 = 180 nM Qpatch and 280 nM whole cells) and selective inhibitor of TRPC4 and 5.1 It displayed excellent selectivity

VU0134992 | Kir4.1 Blocker

VU0134992 (755002-90-5) is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency.

Ischemia

Apixaban | Factor Xa inhibitor

CAS:
503612-47-3
Catalog Number:
10-5660
Activity:
Factor Xa inhibitor
Chemical Names:
4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Molecular Weight:
459.51
Molecular Formula:
C25H25N5O4
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Bepridil | Calcium channel blocker\Active against SARS-CoV2

CAS:
74764-40-2
Catalog Number:
10-4958
Activity:
Calcium channel blocker/anti-SARS-CoV2
Chemical Name:
N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline hydrochloride
Molecular Weight:
403.00
Molecular Formula:
C24H34N2O·HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Lipid Metabolism

Firsocostat | Allosteric acetyl-CoA carboxylase inhibitor

CAS:
1434635-54-7
Catalog Number:
10-4699
Activity:
Allosteric ACC inhibitor
Chemical Names:
2-[1-[(2R)-2-(2-Methoxyphenyl)-2-9oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid
Alternate Name:
ND-630; NDI-010976; GS-0976
Molecular Weight:
569.63
Molecular Formula:
C28H31N3O8S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

BMS-303141 | ATP citrate lyase (ACL) inhibitor

CAS:
943962-47-8
Catalog Number:
10-1414
Activity:
ATP citrate lyase (ACL) inhibitor
Chemical Name:
3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1’-biphenyl]-3-yl)-benzenesulfonamide
Molecular Weight:
424.30
Molecular Formula:
C19H15Cl2NO4S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT