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Cardiovascular

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 1-EBIO | K+ channel activator | CAS 10045-45-1
    $40.00
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 5α,6α-Epoxycholesterol | CAS 1250-95-9
    $25.00
    5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol.  It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AICAR | AMPK activator | CAS 2627-69-2
    $30.00
    Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amiodarone HCl | PDE inhibitor | CAS 19774-82-4
    $45.00
    Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93...

  • Focus Biomolecules cell signaling reagent supplier, structure of Amlodipine | L-type Ca channel blocker | CAS 88150-42-9
    $30.00
    Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Argatroban | Thrombin inhibitor | CAS 74863-84-6
    $56.00
    Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM)1. Prevents platelet-rich arterial thrombosis in a rabbit model2. Ameliorates early brain injury and improves neurological outcomes after...

  • Focus Biomolecules cell signaling supplier, chemical structure AS-8351 | KDM5B histone demethylase inhibitor | CAS 796-42-9
    $50.00
    AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Atglistatin | ATGL inhibitor | CAS 1469924-27-3
    $60.00
    Atglistatin (1469924-27-3) is the first small molecule inhibitor of adipose triglyceride lipase (ATGL) – IC50 = 700 nM.1  It exhibits high selectivity for ATGL, is active in vitro and in vivo, and does not inhibit...

  • BMS-303141 | ATP citrate lyase (ACL) inhibitor
    $70.00
    BMS-303141 (943963-47-8) is a potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells.1,2 Reduces weight gain, lowers plasma cholesterol,...

  • Focus Biomolecules reagent supplier, chemical structure Captopril | Angiotensin-converting enzyme inhibitor | CAS 62571-86-2
    $30.00
    Captopril (62571-86-2) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cilostamide | PDE3 inhibitor | CAS 68550-75-4
    $60.00
    Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM)1,2. Blocks PKB/Akt signaling pathway downstream via inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cilostazol | PDE3A inhibitor | CAS 73963-72-1
    $40.00
    Cilostazol (73963-72-1) is a clinically approved phosphodiesterase III (PDE3) inhibitor (IC50 = 0.2 μM) and anti-thrombotic agent. It inhibits platelet aggregation and is a direct arterial vasodilator...

  • Citalopram HBr | Serotonin uptake inhibitor
    $52.00
    Citalopram (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of...

  • Focus Biomolecules supplier, chemical structure Cyclothiazide | AMPA receptor positive allosteric modulator | CAS 2259-96-3
    $50.00
    Cyclothiazide (2259-96-3) is a positive allosteric modulator of AMPA receptors acting at a site distinct from that of 2,3-benzodiazepines.1,2 Clinically useful diuretic and antihypertensive agent.3 Induces robust...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Diazoxide | KATP channel activator | CAS 364-98-7
    $40.00
    Activates ATP-dependent K+ channels1 via inducing translocation of PKC-epsilon from the cytosol to the mitochondria2. Hyperglycemic agent. Induces powerful protective effects against cardiac ischemia via multiple mechanisms...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Diltiazem | Calcium channel blocker | CAS 33286-22-5
    $30.00
    Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels1,2.Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells3. Also blocks P-type Ca2+ channels in...

  • Focus Biomolecules cell signaling supplier, chemical structure of Dipyridamole | Pan-specific PDE inhibitor | CAS 58-32-2
    $22.00
    Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Disopyramide | Antiarrhythmic | CAS 3737-09-5
    $35.00
    Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2.  It decreases the rate of diastolic...

  • Focus Biomolecules cell signaling reagent supplier, structure of Dofetilide | hERG channel blocker | CAS 115256-11-6
    $65.00
    Dofetilide (115256-11-6) is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel.1,2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    $60.00
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

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