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Arrhythmia

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amiodarone HCl | PDE inhibitor | CAS 19774-82-4
    $45.00
    Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Disopyramide | Antiarrhythmic | CAS 3737-09-5
    $35.00
    Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2.  It decreases the rate of diastolic...

  • Focus Biomolecules cell signaling reagent supplier, structure of Dofetilide | hERG channel blocker | CAS 115256-11-6
    $65.00
    Dofetilide (115256-11-6) is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel.1,2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure E-4031 | hERG channel blocker | CAS 113558-89-7
    $98.00
    E-4031 (113558-89-7) is a selective hERG potassium channel blocker. Inhibits the rapid delayed-rectifier K+ current (IKr). Class III antiarrhythmic agent. Cell permeable. References/Citations1) Ficker et al. (2002), The...

  • Focus Biomolecules supplier, chemical structure of GBR-12909 2HCl | Dopamine reuptake inhibitor | CAS 67469-78-7
    $60.00
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • Norfluoxetine HCl | Fluoxetine Metabolite
    $60.00
    Norfluoxetine HCl (57226-68-3) is a metabolite of fluoxetine.3 Induces long QT syndrome via slow delayed rectifier potassium current block.1 Time dependent inhibitor of CYP2C19 and CYP3A4.2   The S-isomer of...

  • Focus Biomolecules cell signaling reagent supplier, structure of Verapamil HCl | L-type Ca channel blocker | CAS 152-11-4
    $27.00
    Verapamil HCl (152-11-4) is a clinically useful L-type calcium channel blocker.1 It is also used as an inhibitor of drug efflux pump proteins.2 References/Citations1) Brgden and Benfield (1996) Verapamil: a review of its...

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