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  • Amiodarone HCl | PDE inhibitor
    Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93...

  • Disopyramide | Antiarrhythmic
    Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2.  It decreases the rate of diastolic...

  • Dofetilide | 115256-11-6 | Structure | Suplier
    Dofetilide (115256-11-6) is a clinically useful class III antiarrhythmic that inhibits the rapid component of the delayed rectifier outward potassium current (IKr) via selective blockage of the Kv11.1 (hERG) channel...

  • E-4031 | 113558-89-7 | Structure | Supplier
    E-4031 (113558-89-7) is a selective hERG potassium channel blocker. Inhibits the rapid delayed-rectifier K+ current (IKr). Class III antiarrhythmic agent. Cell permeable. References/Citations1) Ficker et al. (2002), The...

  • FTY720 HCl | Sphingosine-1-phosphate receptor agonist
    FTY720 HCl (162359-56-0) is an analog of sphingosine (Cat.# 10-2287) which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).1 Potently inhibits regulatory...

  • GBR-12909 2HCl | Dopamine reuptake inhibitor
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • Verapamil HCl | 152-11-4 | Structure | Supplier
    Verapamil HCl (152-11-4) is a clinically useful L-type calcium channel blocker.1 It is also used as an inhibitor of drug efflux pump proteins.2 References/Citations1) Brgden and Benfield (1996) Verapamil: a review of its...

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