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  • Citalopram HBr | Serotonin uptake inhibitor
    Citalopram (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of...

  • EPA free acid | 10417-94-4 | Structure | Supplier
    EPA free acid (10417-94-4) dietary enrichment may have anti-inflammatory effects by inhibiting the 5-lipoxygenase pathway and LTB4-mediated neutrophil functions.1 Displays various cardiovascular protective properties...

  • Leonurine | Neuroinflammation inhibitor
    Inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways.1 Inhibits the formation of advanced glycation end products.2 Ameliorates cognitive...

  • Mitoquinone | 444890-40-9 | Structure | Supplier
    Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer's disease.2 Mitoquinone protects pancreatic...

  • Necrostatin-1 | 4311-88-0 | Structure | Supplier
    Necrostatin-1 (4311-88-0) is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2...

  • Ro 13-6438 | Quazinone | 70018-51-8 | Structure | Supplier
    Ro 13-6438 (70018-51-8) is a selective inhibitor of phosphodiesterase III (PDE III, IC50 = 0.6 μM). References/Citations1) Eigenmann et al. (1984) Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent...

  • U-74389G | Free radical scavenger
    U-74389G (153190-29-5) is an antioxidant and Inhibits iron-mediated lipid peroxidation.1 It has also been shown to reduce free radical-mediated injury after ischemia and reperfusion.2,3 References/Citations1) Braughler et...

  • Visnagin| Protects against doxorubicin-induced cardiomyopathy
    Visnagin (82-57-5) is a natural product isolated from the plant Ammi visnaga.  It displays protective effects against doxorubicin-induced cardiomyopathy via inhibition of mitochondrial malate dehydrogenase resulting in...

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