E-4031 | hERG channel blocker

E-4031 (113558-89-7) is a selective hERG potassium channel blocker. Inhibits the rapid delayed-rectifier K+ current (IKr). Class III antiarrhythmic agent. Cell permeable.

References/Citations
1) Ficker et al. (2002), The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo gene (HERG) mutations; J. Biol. Chem., 277 4989
2) Wettwer et al. (1991), Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysical parameters; J. Cardiovasc. Pharmacol., 17 480

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

10 mg, 50 mg

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CAS:
113558-89-7
Catalog Number:
10-1213
Activity:
hERG channel blocker
Chemical Name:
N-[4-[[1-[2-(6-Methyl-3-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride dihydrate
Molecular Weight:
510.47
Molecular Formula:
C21H27N3O3S _ 2HCl 2(H2O)
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

E-4031 | hERG channel blocker

$98.00$392.00

CAS:
113558-89-7
Catalog Number:
10-1213
Activity:
hERG channel blocker
Chemical Name:
N-[4-[[1-[2-(6-Methyl-3-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride dihydrate
Molecular Weight:
510.47
Molecular Formula:
C21H27N3O3S _ 2HCl 2(H2O)
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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