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Heart Failure

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  • Disopyramide | Antiarrhythmic
    Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2.  It decreases the rate of diastolic...

  • FTY720 HCl | Sphingosine-1-phosphate receptor agonist
    FTY720 HCl (162359-56-0) is an analog of sphingosine (Cat.# 10-2287) which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).1 Potently inhibits regulatory...

  • Nicardipine HCl | L-type Ca channel blocker / MDR inhibitor
    Nicardipine (54527-84-3) is a clinically useful L-type calcium blocker. Inhibitor of MDR.2 References/Citations1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the...

  • Pyr3 | 1160514-60-2 | Structure | Supplier
    Pyr3 (1160514-60-2) is a selective antagonist of the TRP canonical 3 channel (TRPC3)1 which can function as a receptor-operated channel2. A useful tool for dissecting GPCR-downstream signaling mechanisms3. Pyr3 may be...

  • Teprenone | HSP70 inducer
    Teprenone (6809-52-5) induces expression of HSP70 after various types of stimuli.1,2 Protects against visceral adipocity and insulin resistance in high fat fed mice.3 Teprenone displays protective effects via enhanced...

  • Valsartan | Angiotensin antagonist
    Valsartan (137862-53-4) is a high affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors1,2. Normalizes the increased production of inflammatory cytokines in adipose...

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