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Stem Cells

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  • 1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

  • 6BIO | 667463-62-9 | Structure | Supplier
    6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells...

  • AS-8351 | 796-42-9 | Structure | Supplier
    AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the...

  • Dorsomorphin | 866405-64-3 | Structure | Supplier
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • IWP-2 | 686770-61-1 | Structure | Supplier
    IWP-2 (686770-61-6) is an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50= 27 nM) by inhibition of the O-acyltransferase Porcn1. Induces cardiomyocyte differentiation from human pluripotent...

  • KY-02111 | 1118807-13-8 | Structure  | Supplier
    KY-02111 (1118807-13-8) promotes cardiac differentiation of human pluripotent stem cells. Inhibits Wnt signaling in a manner that appears to be distinct from previously described Wnt inhibitors.1 Cell permeable and active in...

  • SHZ-1 | Stem Cell - Myocardial differentiation
    SHZ-1 (326886-05-9) triggers cardiac mRNA and protein expression in a variety of embryonic and adult stem/progenitor cells including human mobilized peripheral blood mononuclear cells (M-PBMC).1 A lead compound for the...

  • XAV-939 | 284028-89-3 | Structure | Supplier
    XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).  Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1  XAV-939...

  • Zebularine | DNA methylation inhibitor
    Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine...

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