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Lycorine HCl | Protein synthesis inhibitor/SCAP degrader

CAS:
2188-68-3
Catalog Number:
10-2608
Activity:
Protein synthesis inhibitor/SCAP degrader
Chemical Names:
Galanthidine; Amarylline; Narcissine
Molecular Weight:
323.77
Molecular Formula:
C16H17NO4·HCl
Solubility:
Soluble in water (15 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM).4 A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

References:

  1. Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168
  2. Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483
  3. Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407
  4. Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174
  5. Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1

 

Lycorine HCl | Protein synthesis inhibitor/SCAP degrader is also available in the Cellular Metabolism Library.
CAS:
2188-68-3
Catalog Number:
10-2608
Activity:
Protein synthesis inhibitor/SCAP degrader
Chemical Names:
Galanthidine; Amarylline; Narcissine
Molecular Weight:
323.77
Molecular Formula:
C16H17NO4·HCl
Solubility:
Soluble in water (15 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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