my account
Login
  Loading... Please wait...

Mitosis

Sort by
  • Focus Biomolecules cell signaling tech supplier, chemical structure of Colchicine | Microtubule depolymerizer | CAS 64-86-8
    $40.00
    Colchicine (64-86-8) is a naturally occurring alkaloid which acts as an antimitotic agent by binding to tubulin and depolymerizing microtubules. Colchicine induces apoptosis in a variety of cell lines. References/Citations1)...

  • Divin | Divisome assembly inhibitor
    $75.00
    Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to...

  • Focus Biomolecules supplier, chemical structure of Docetaxel | Microtubule stabilizing agent | CAS 114977-28-5
    $35.00
    Docetaxel (114977-28-5) is an antimitotic chemotherapeutic which inhibits via reversible high-affinity binding to microtubules1. Induces apoptosis in a variety of cancer cell lines2 however, tumor cells can quickly develop...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Enzastaurin | PKC inhibitor | CAS 170364-57-5
    $60.00
    Enzastaurin (170364-57-5) is a potent and selective PKCβ inhibitor.  IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell...

  • Focus Biomolecules reagent supplier, chemical structure of Forchlorfenuron | Inhibits septin dynamics | CAS 86157-80-6
    $40.00
    Forchlorfenuron (86157-80-6) reversibly perturbs mammalian septin assembly, organization and function.  Has no effect on actin or tubulin polymerization.1,2 FCF induces effects on mitosis and migration which phenocopy...

  • FQI1 | LSF inhibitor
    $70.00
    FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular...

  • Focus Biomolecules reagent supplier, chemical structure of Griseofulvin | Inhibitor of centrosomal clustering | CAS 126-07-8
    $30.00
    Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the...

  • Focus Biomolecules supplier, chemical structure of Importazole | Blocks importin-β-mediated nuclear import | CAS 662163-81-7
    $50.00
    Importazole (662163-81-7) specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.1 When added to cells during mitosis,...

  • Focus Biomolecules supplier, chemical structure of Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor | CAS 160807-49-8
    $60.00
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of K-858 | Kinesin Eg5 inhibitor | CAS 72926-24-0
    $60.00
    K858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily...

  • Focus Biomolecules supplier, chemical structure of Monastrol | Kinesin Eg5 and mitosis inhibitor | CAS 254753-54-3
    $80.00
    Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PJ-34 HCl | PARP1,2 inhibitor | CAS 344458-15-7
    $65.00
    PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM1. Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia...

  • Focus Biomolecules cell signaling reagent supplier, structure S-Trityl-cysteine | Kinesin Eg5 inhibitor | CAS 2799-07-7
    $35.00
    S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TAME | Ubiquitin ligase inhibitor | CAS 1784-03-8
    $45.00
    TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2 References/Citations1) Zeng et al. (2010) Pharmacologic...

  • Focus Biomolecules supplier, chemical structure of Taxol | Microtubule stabilizing agent | CAS 33069-62-4
    $25.00
    Taxol (33069-62-4) is a clinically useful cancer chemotherapeutic agent for the treatment of breast, non-small cell lung and ovarian cancer.1 Taxol acts as a promoter of tubulin polymerization and stabilizes microtubules in...

  • Focus Biomolecules supplier, chemical structure of Vinblastine sulfate | Microtubule depolymerizer | CAS 143-67-9
    $48.00
    Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant...

  • Focus Biomolecules supplier, chemical structure of Vincristine sulfate | Microtubule depolymerizer | CAS 2068-78-2
    $30.00
    Vincristine sulfate (2068-78-2) arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins.1,2 Induces apoptosis...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus