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Cell death can be divided in two major categories. Necrosis results from cellular injury caused by external factors such as trauma or infection. Programmed cell death is a regulated process that is mediated by various intracellular programs. Types of programmed cell death include apoptosis, anoikis, necroptosis, ferroptosis, pyroptosis, and parthanatos. These types of programmed cell death other than apoptosis have also been termed stress-induced cell death (SCID).
Apoptosis
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Cell permeable, irreversible, pan-caspase inhibitor
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Staurosporine is a pan-kinase inhibitor widely used to induce apoptosis
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Cell permeable ceramide analog that induces apoptosis in a wide variety of cell types
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Obatoclax is a pan-inhibitor of Bcl-2-family proteins
Necroptosis
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Selective inhibitor of RIP1
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GSK872 is a potent and selective inhibitor of RIP3 that blocks necroptosis and necrosis
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Potent and selective inhibitor of RIP1
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MLKL inhibitor that blocks necroptosis downstream of RIP3
Ferroptosis
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Induces ferroptosis via inhibition of the cystine-glutamate antiporter, system Xc-
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Ferrostatin-1 is a potent inhibitor of ferroptosis
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