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Cell Death

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  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    $50.00
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • Focus Biomolecules cell signaling reagent supplier, structure of 3-Aminobenzamide | PARP inhibitor | CAS 3544-24-9
    $50.00
    3-Aminobenzamide (3544-24-9) inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. 3-Aminobenzamide has been...

  • Focus Biomolecules supplier, chemical structure of 5-Fluorouridine | Proapoptotic antiproliferative agent | CAS 316-46-1
    $70.00
    5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1  Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms...

  • 7-Aminoactinomycin D | Fluorescent DNA Probe
    $74.00
    7-Aminoactinomycin D (7240-37-1) is a fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry. 1,2 Capable of identifying populations representing live, apoptotic, and late...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 7-Cl-O-Nec1 | RIP1 inhibitor | CAS 852391-15-2
    $50.00
    7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of...

  • Focus Biomolecules supplier, chemical structure of Actinonin | Leucyl aminopeptidase inhibitor | CAS 13434-13-4
    $35.00
    Actinonin (13434-13-4) is a potent hydroxamic acid inhibitor of aminopeptidases which displays analgesic effects by inhibiting enkephalin-degrading enzymes.1 Actinonin also inhibits peptide deformylase.2 Induces...

  • Focus Biomolecules cell signaling reagent supplier, structure Adapalene | Retinoid RARŒ≤, RARŒ≥ agonist | CAS 106685-40-9
    $30.00
    Adapalene (106685-40-9) is a stable analog of retinoic acid that acts as a selective agonist for RARβ and RARγ. Adapalene also inhibits proliferation and induces apoptosis in colorectal cancer cells in culture...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ALLN | Calpain inhibitor | CAS 110044-82-1
    $50.00
    ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and...

  • Focus Biomolecules supplier, chemical structure of Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor | CAS 237430-03-4
    $56.00
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amifostine | Cellular protectant | CAS 20537-88-6
    $56.00
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.2-4...

  • Focus Biomolecules supplier, Andrographolide | Induces mitochondrial-mediated apoptosis in lymphoma cells | CAS 5508-58-7
    $34.00
    Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Anisomycin | Anoikis sensitizer | CAS 22862-76-6
    $35.00
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

  • Focus Biomolecules supplier, chemical structure of Ansamitocin P3 | Microtubule depolymerizer | CAS 66547-09-9
    $50.00
    Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity...

  • Focus Biomolecules supplier, chemical structure of Aphidicolin | DNA polymerase inhibitor | CAS 38966-21-1
    $70.00
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apoptolidin | Apoptosis inducer | CAS 194874-06-1
    $248.00
    Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AT-101 | Bcl-2 inhibitor | CAS 90141-22-3
    $116.00
    AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of b-AP15 | DUB inhibitor | CAS 1009817-63-3
    $60.00
    b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BADGE | PPAR gamma antagonist | CAS 1675-54-3
    $30.00
    BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional...

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