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  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 7-Cl-O-Nec1 | RIP1 inhibitor | CAS 852391-15-2
    7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ALLN | Calpain inhibitor | CAS 110044-82-1
    ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1 Inhibits cell cycle progression at G1/S and...

  • Focus Biomolecules supplier, chemical structure of GSK872 | Necroptosis inhibitor | RIP3 inhibitor | CAS 1346546-69-7
    GSK 872 (CAS 1346546-60-7) is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced...

  • Focus Biomolecules cell signaling supplier, chemical structure Matrine | Induces RIP3-dependent necroptosis | CAS 519-02-8
    Matrine (519-02-8) is a natural product found in the plant Sophora flavescens.  It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic...

  • Focus Biomolecules cell signaling reagent supplier, structure of Necrostatin-1 | Inhibits necroptosis | CAS 4311-88-0
    Necrostatin-1 (4311-88-0) is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of RIPA-56 | RIP1 kinase | CAS 1956370-21-0
    RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver...

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