Necroptosis
Showing all 7 results
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Cell Death
24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agon...$50.00 – $245.00 Select options -
Cell Death
7-Cl-O-Nec1 | RIP1 inhibitor
7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stab...$50.00 – $185.00 Select options -
Calpains
ALLN | Calpain inhibitor
ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and ot...$50.00 – $188.00 Select options -
Cell Death
GSK872 | Necroptosis inhibitor / RIP3 inhibitor
GSK 872 (CAS 1346546-60-7) is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting...$70.00 – $275.00 Select options -
Cancer
Matrine | Induces RIP3-dependent necroptosis
Matrine (519-02-8) is a natural product found in the plant Sophora flavescens. It has been found to possess myriad biological activities including...$30.00 – $80.00 Select options -
Cardioprotection
Necrostatin-1 | Inhibits necroptosis
Necrostatin-1 (4311-88-0) is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain ...$65.00 – $165.00 Select options -
Cell Death
RIPA-56 | RIP1 kinase
RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kin...$40.00 – $135.00 Select options
