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Cellular Metabolism

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CPI-613 | KGDH and PDH inhibitor | CAS
    $50.00
    CPI-613 (95809-78-2) is a lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1   Inhibits alpha-ketoglutarate...

  • Focus Biomolecules, chemical structure CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase | CAS 166981-13-1
    $125.00
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • Focus Biomolecules reagent supplier, chemical structure of Deoxymannojirimycin HCl | Mannosidase inhibitor | CAS 73465-43-7
    $35.00
    Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and...

  • Focus Biomolecules supplier, chemical structure of Deoxynojirimycin | Glucosidase inhibitor | CAS 19130-96-2
    $50.00
    Deoxynojirimycin (19130-96-2) inhibits α-glucosidase I and II1,2. Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step3. May be used to produce an affinity...

  • Focus Biomolecules supplier, structure of Difluoromethylornithine HCl | Inhibits polyamine biosynthesis | CAS 96020-91-6
    $30.00
    Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1 Induces apoptosis in a variety of cells.2 Difluoromethylornithine HCl displays cancer chemopreventive activity...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DU-14 | Sulfatase inhibitor | CAS 186303-55-9
    $72.00
    DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats1. Inhibits proliferation of human MCF-7 breast cancer cells2. References/Citations1) Johnson et al. (2000), The...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Enasidenib | Inhibitor of IDH2 | CAS 1446502-11-9
    $55.00
    Enasidenib (1446502-114-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2)...

  • Focus Biomolecules supplier, chemical structure of Eniluracil | Dihydropyrimidine dehydrogenase inhibitor | CAS 59989-18-3
    $40.00
    Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1,2,3  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). ...

  • Epacadostat | IDO1 inhibitor
    $60.00
    Epacadostat (1204669-58-8) is a potent (IC50 = 10nM)1 and selective inhibitor of Indoleamine-2,3-dioxygenase 1 (IDO1) with no activity at IDO2 or TDO.2 It restored tryptophan levels and significantly impaired kynurenine...

  • Fasentin | Glucose uptake inhibitor
    $55.00
    Fasentin (392721-37-8) is a novel inhibitor of glucose uptake which acts via inhibition of the glucose transporter GluT1 and GluT4 (IC50=68 μM).1 Inhibition of glucose uptake is cell type specific2 and is a promising...

  • Focus Biomolecules cell signaling supplier, chemical structure Fasnall HCl | Fatty acid synthase inhibitor | CAS 929978-58-5
    $64.00
    Fasnall (CAS 929978-58-5) is a potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose...

  • Focus Biomolecules supplier, chemical structure of FCCP | Inhibits mitochondrial oxidative phosphorylation | CAS 370-86-5
    $58.00
    FCCP (370-86-5) is an extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic...

  • Focus Biomolecules cell signaling supplier, chemical structure of FK-866 HCl | NAD biosynthesis inhibitor | CAS 658084-64-1
    $90.00
    FK866 HCl (658084-64-1 base) is a nicotinamide phosphoribosyltransferase inhibitor (Ki=0.4 nM). Induces tumor cell apoptosis. FK-866 HCl extends lifespan of human cells. Cell permeable. References/Citations 1) Hasmann et al...

  • Focus Biomolecules cell signaling supplier, chemical structure Fluvastatin Na | HMG CoA reductase inhibitor | CAS 93957-55-2
    $30.00
    Fluvastatin Na (CAS 93957-55-2) is a potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1  Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FSG67 | GPAT inhibitor | CAS 1158383-34-6
    $55.00
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • GAC inhibitor 968 | Glutaminase C inhibitor
    $60.00
    GAC inhibitor 968 (311765-38-7) is an allosteric inhibitor of glutaminase C (GAC).1 Inhibition of GAC blocks oncogenic transformation induced by Rho GTPases in fibroblasts and B lymphoma cells with no effect on normal cells...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of L-Glutamyl γ-(p-nitroanilide) HCl | CAS 67953-08-6
    $20.00
    L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric...

  • Focus Biomolecules supplier, chemical structure of Gimeracil | Dihydropyrimidine dehydrogenase inhibitor | CAS 103766-25-2
    $50.00
    Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.  DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).  Gimeracil is used along...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-501516 | PPAR delta agonist | CAS 317318-70-0
    $68.00
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HQNO | NADH oxidase inhibitor | CAS 341-88-8
    $85.00
    HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent...