my account
Login
  Loading... Please wait...

Cellular Metabolism

Sort by
  • iGP-1 | Mitochondrial GPDH inhibitor
    $50.00
    iGP-1 (27031-00-1) is a potent and cell permeable inhibitor of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 μM, that is selective over the cytosolic enzyme1. It does not block pyruvate uptake into...

  • Focus Biomolecules reagent supplier, chemical structure of Indoximod | IDO modulator / tryptophan mimetic | CAS 110117-83-4
    $20.00
    Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer...

  • IntelliScreen Cancer Cell Metabolism Library 3 plates 100 ul/well
    $4,300.00
    Concentrations vary based on effective concentrations - please contact us for a complete library compound list.

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of IPBT-5CA | GPR109B agonist | CAS 306935-41-1
    $35.00
    IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a...

  • Focus Biomolecules, chemical structure Isofagomine tartrate | Glucocerebrosidase activator, chaperone | CAS 957230-65-8
    $100.00
    Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50 = 0.06 μM.1 Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of JNJ-1661010 | FAAH inhibitor | CAS 681136-29-8
    $80.00
    JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure JZL-184 | MAG lipase inhibitor | CAS 1101854-58-3
    $62.00
    JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable. References/Citations1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Kifunensine | Mannosidase inhibitor | CAS 109944-15-2
    $80.00
    Historically isolated from Kitasatosporia kifunense.1 Kifunensine (CAS 109944-15-2) is an inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum...

  • Focus Biomolecules, chemical structure Koningic acid | Glyceraldehyde-3-phosphate dehydrogenase inhibitor | CAS 74310-84-2
    $200.00
    Koningic acid (KA; 74310-84-2) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1  Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the...

  • L-Buthionine Sulfoximine | GCL inhibitor
    $50.00
    L-Buthionine sulfoximine (83730-53-4) is an irreversible inhibitor of γ-glutamylcysteine ligase (GCL). GCL is the first enzyme of the cellular glutathione biosynthetic pathway. Dysregulation of glutathione homeostasis...

  • Leelamine | Intracellular cholesterol inihibitor
    $50.00
    Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Leflunomide | Immunosuppressant | CAS 75706-12-6
    $40.00
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

  • Focus Biomolecules cell signaling supplier, chemical structure Lonidamine | Inhibits Cancer Cell Metabolism | CAS 50264-69-2
    $45.00
    Lonidamine (50264-69-2) was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2...

  • Focus Biomolecules supplier, chemical structure of LY-2183240 | Anandamide uptake inhibitor | CAS 874902-19-9
    $60.00
    LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2,3,4 to be an inhibitor of fatty acid amide hydrolase (FAAH) - IC50 = 14nM4,...

  • Manumycin A | Farnesyltransferase inhibitor
    $100.00
    Manumycin A (52665-74-4) inhibits ras farnesyltransferase1 and prevents ras signaling2. Irreversibly inhibits neutral sphingomyelinase3. Abrogates IL-1β-induced HIF-1α activation in both glioma and non-glioma...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Metformin HCl | Anti-diabetic agent | CAS 1115-70-4
    $30.00
    Metformin HCl (1115-70-4) is a clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis by activation of the AMP-activated protein kinase (AMPK)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MF-438 | SCD1 inhibitor | CAS 921605-87-0
    $60.00
    MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and 3 mg/kg).1 Cancer initiating cells (CSC-like) were...

  • Focus Biomolecules supplier, chemical structure of Miglitol | beta-glucosidase inhibitor / antidiabetic | CAS 72432-03-2
    $60.00
    Miglitol (72432-03-2) is an α-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans1. Miglitol displays...

  • Focus Biomolecules cell signaling supplier, chemical structure Miglustat HCl | Alpha-glucosidase inhibitor | CAS 210110-90-0
    $110.00
    Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of...

  • Focus Biomolecules, structure Mitoguazone 2HCl | Polyamine biosynthesis / SAM decarboxylase inhibitor | CAS 31959-87-2
    $70.00
    Mitoguazone (7059-23-6) is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in...