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Cellular Metabolism

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MRL-24 | PPARγ partial agonist | CAS 393794-17-7
    $65.00
    MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. MRL-24 is highly effective (30 nM) at blocking...

  • Focus Biomolecules supplier, chemical structure of Myriocin | Blocks sphingolipid biosynthesis | CAS 35891-70-4
    $65.00
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of N-Oleoylphenylalanine
    $50.00
    N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler...

  • NGI-1 | Oligosaccharyltransferase (OST) inhibitor
    $55.00
    NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 µM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of NHI-2 | LDHA inhibitor | CAS 1269802-97-2
    $95.00
    NHI-2 (1269802-97-2) is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50 in vitro = 14.7 μM (NADH), 10.5 μM (Pyruvate).1 NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Nonylbenzeneboronic acid | FAAH | CAS 256383-45-6
    $30.00
    Nonylbenzeneboronic acid (CAS 256383-45-6) is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase...

  • Focus Biomolecules supplier, chemical structure of Oligomycin Complex | Mitochondrial ATPase inhibitor | CAS 1404-19-9
    $57.00
    Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male...

  • Focus Biomolecules cell signaling tech supplier, chemical structure Orlistat | DAG Lipase-alpha inhibitor | CAS 96829-58-2
    $30.00
    Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of P7C3 | Neuroprotective agent | CAS 301353-96-8
    $60.00
    P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant...

  • Pemetrexed 2Na | Multitargeted antifolate
    $40.00
    Pemetrexed (357166-29-1) is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Perphenazine | Antipsychotic agent | CAS 58-39-9
    $25.00
    Perphenazine (58-39-9) is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and...

  • PF-06840003 | IDO1 inhibitor
    $60.00
    PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PF-622 | FAAH inhibitor | CAS 898235-63-9
    $80.00
    PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable...

  • PF-9366 | Methionine adenosyltransferase 2A inhibitor
    $60.00
    PF-9366 (72882-78-1) is an allosteric inhibitor (IC50 = 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1 It inhibited cellular...

  • Focus Biomolecules supplier, chemical structure of PFK15 | Phosphofructo-2-kinase (PFKFB3) inhibitor | CAS 4382-63-2
    $45.00
    PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).  PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Piperlongumine | Glutathione sponge | CAS 20069-09-4
    $30.00
    Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular...

  • Focus Biomolecules supplier, chemical structure of PluriSln#1 | Stearoyl CoA desaturase inhibitor | CAS 91396-88-2
    $50.00
    PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated...

  • Focus Biomolecules cell signaling supplier, chemical structure of POB | Ornithine decarboxylase inhibitor | CAS 946135-39-3
    $70.00
    POB is a transition state-based, cell permeable pro-drug inhibitor of ODC, a key enzyme involved in polyamine synthesis and a potential cancer drug target. Intracellularly, POB is phosphorylated by pyridoxal kinase and the...

  • Focus Biomolecules supplier, chemical structure of Propargylglycine | H2S synthase inhibitor | CAS 64165-64-6
    $38.00
    Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in...

  • Focus Biomolecules cell signaling supplier, chemical structure R162 | Glutamate dehydrogenase 1 inhibitor | CAS 64302-87-0
    $50.00
    R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki = 28.6 µM).  It does not inhibit the activity of other NADPH enzymes such as...