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Cellular Metabolism

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure RHC-80267 | DAG Lipase inhibitor | CAS 83654-05-1
    $55.00
    RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic...

  • Focus Biomolecules cell signaling supplier, chemical structure of SR-8278 | REV-ERB alpha antagonist | CAS 125944-66-5
    $78.00
    SR-8278 (125944-66-5) is an antagonist of the nuclear heme receptor, REV-ERB. Blocks the ability of the REV-ERBα agonist, GSK4112, to enhance REV-ERB-dependent repression in a cotransfection assay.1 Decreases glucagon...

  • Focus Biomolecules supplier, chemical structure of SR-9009 | RevErb alpha & beta agonist | CAS 1379686-30-2
    $70.00
    SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SR9243 | LXR inverse agonist | CAS 1613028-81-1
    $45.00
    SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types...

  • SRT1720 HCl | SIRT1 activator
    $75.00
    SRT1720 is a SIRT1 activator (EC1.5 = 0.16 µM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob/obmice and Zucker fa/fa rats.  SRT1720 enhanced endurance running and protected...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-31 | NAMPT inhibitor | CAS 724741-75-7
    $90.00
    STF-31 (724741-75-7) is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene)...

  • Focus Biomolecules reagent supplier, chemical structure of Sulfasalazine | Anti-inflammatory / antibiotic | CAS 599-79-1
    $20.00
    Sulfasalazine (599-79-1) is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release...

  • Focus Biomolecules cell signaling supplier, chemical structure of Swainsonine | Glycosidase inhibitor | CAS 72741-87-8
    $70.00
    Swainsonine (72741-87-8) is a naturally occurring alkaloidal toxin found in locoweed. Inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II (IC50 = 0.2 mM).1 Inhibits growth and potentiates...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TH588 | MTH1/NUDT1 inhibitor | CAS 1609960-31-7
    $55.00
    TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of THI | Immunomodulator | CAS 94944-70-4
    $60.00
    THI (94944-70-4) was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering...

  • Focus Biomolecules cell signaling supplier, chemical structure Thiamet G | O-GlcNAcase antagonist | CAS 1009816-48-1
    $70.00
    Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and in vivo. Suppresses phosphorylation of tau...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TMP-153 | ACAT inhibitor | CAS 128831-46-9
    $36.00
    TMP-153 (128831-46-9) is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.1,2 TMP-153...

  • Focus Biomolecules supplier, chemical structure of TOFA | Acyl-CoA carboxylase inhibitor | CAS 54857-86-2
    $50.00
    TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1)1. Induces apoptosis in a variety of tumor cell lines2,3. Stimulates neurite outgrowth and neuronal differentiation in rat...

  • Focus Biomolecules supplier, chemical structure of Tolcapone | COMT inhibitor | TTR aggregation inhibitor | CAS 134308-13-7
    $50.00
    Tolcapone (134308-13-7) is a catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting...

  • Focus Biomolecules supplier, chemical structure of Triacsin C | Acyl-CoA synthase inhibitor | CAS 76896-80-5
    $90.00
    Triacsin C (76896-80-5) is a long-chain fatty acyl CoA synthetase inhibitor (IC50=3.6-8.7 μM)1. Inhibits mouse macrophage-derived foam cell formation2 and displays anti-atherosclerotic activity3. Cell permeable...

  • Focus Biomolecules cell signaling supplier, chemical structure of TTFA | Mitochondrial Complex II inhibitor | CAS 326-91-0
    $25.00
    TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tunicamycin | ER stress inducer | CAS 11089-65-9
    $74.00
    Tunicamycin (11089-65-9) is a fermentation product from Streptomyces lysosuperificus.  Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs varying in the number of carbon atoms in the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of URB-597 | FAAH inhibitor | CAS 546141-08-6
    $35.00
    URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1 Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side...

  • Focus Biomolecules cell signaling supplier, chemical structure of WZB117 | Glucose transport inhibitor | CAS 1223397-11-2
    $35.00
    WZB117 (1223397-11-2) is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. Daily intraperitoneal...