Cellular Metabolism

Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.

2-NBD-Glucose

Fluorescent glucose uptake probe
SR9243

LXR inverse agonist that reduces glycolytic and lipogenic gene expression
Koningic acid

Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase

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Lipid

FSG67

Inhibitor of glycerol-3-phosphate acyltransferase
MF-438

A potent inhibitor of stearoyl-CoA desaturase 1
BMS-303141

ATP citrate lyase (ACL) inhibitor

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Glutamine

CB-839

Potent and selective inhibitor of glutaminase (KGA and GAC)
R162

Selective inhibitor of glutamate dehydrogenase 1(GDH1)

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Polyamine

Mitoguazone 2HCl

Potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD)
POB

Pro-drug inhibitor of ornithine decarboxylase

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Complex Carbohydrates

Thiamet G

Thiamet G is a potent and selective inhibitor of O-GlcNAcase
NGI-1

NGI-1 is a cell permeable inhibitor of oligosaccharyltransferase (OST)
Kifunensine

Inhibits glycoprotein processing via inhibition of class I a-mannosidases

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