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Cellular Metabolism

Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.

View All Cellular Metabolism Reagents

View Cellular Metabolism Library

Glucose

  • 2-NBD-Glucose

    Fluorescent glucose uptake probe

  • SR9243

    LXR inverse agonist that reduces glycolytic and lipogenic gene expression

  • Koningic acid

    Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase

View All Glucose Reagents

Lipid 

  • FSG67

    Inhibitor of glycerol-3-phosphate acyltransferase

  • MF-438

    A potent inhibitor of stearoyl-CoA desaturase 1

  • BMS-303141

    ATP citrate lyase (ACL) inhibitor

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Glutamine

  • CB-839

    Potent and selective inhibitor of glutaminase (KGA and GAC)

  • R162

    Selective inhibitor of glutamate dehydrogenase 1(GDH1)

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Polyamine 

  • Mitoguazone 2HCl

    Potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD)

  • POB

    Pro-drug inhibitor of ornithine decarboxylase

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Complex Carbohydrates 

  • Thiamet G

    Thiamet G is a potent and selective inhibitor of O-GlcNAcase

  • NGI-1

    NGI-1 is a cell permeable inhibitor of oligosaccharyltransferase (OST)

  • Kifunensine

    Inhibits glycoprotein processing via inhibition of class I a-mannosidases

View All Complex Carbohydrates

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