Cellular Metabolism

Focus Biomolecules offers a diverse and expanding portfolio of small molecule reagents for the study of various components and pathways related to cellular metabolism. We also offer the FCCC Cellular Metabolism Library, a cutting edge screening tool for the study of these pathways and their role in human disease.

Daily function of cells involves many biochemical pathways that continuously monitor and balance critical cellular components. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) manifest in a variety of ways and can hugely impact the daily lives of those affected.

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Glucose

NHI-2

A selective inhibitor of Lactate Dehydrogenase A
2-NBD-Glucose

A fluorescent glucose uptake probe
SR9243

An LXR inverse agonist
WBZ117

An inhibitor of Glucose Transporter 1

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Lipid

MF-438

A potent inhibitor of stearoyl-CoA desaturase 1
Cerulenin

A fatty acid synthase (FAS) inhibitor
Orlistat

A lipase inhibitor which blocks the biosynthesis of 2-AG
CT-2584

A cytotoxic agent that alters phospholipid biosynthesis

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Glutamine

CB-839

Glutaminase Inhibitor
R162

Glutamate Dehydrogenase 1 Inhibitor

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Polyamine

Difluoromethylornithine HCl

A selective inhibitor of ornithine decarboxylase
POB

A transition state-based, cell permeable pro-drug inhibitor
Mitoguazone · 2HCl

A potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC)

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Cellular Metabolism