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Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.
Glucose
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Fluorescent glucose uptake probe
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LXR inverse agonist that reduces glycolytic and lipogenic gene expression
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Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase
Lipid
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Inhibitor of glycerol-3-phosphate acyltransferase
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A potent inhibitor of stearoyl-CoA desaturase 1
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ATP citrate lyase (ACL) inhibitor
Glutamine
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Potent and selective inhibitor of glutaminase (KGA and GAC)
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Selective inhibitor of glutamate dehydrogenase 1(GDH1)
Polyamine
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Potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD)
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Pro-drug inhibitor of ornithine decarboxylase
Complex Carbohydrates
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Thiamet G is a potent and selective inhibitor of O-GlcNAcase
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NGI-1 is a cell permeable inhibitor of oligosaccharyltransferase (OST)
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Inhibits glycoprotein processing via inhibition of class I a-mannosidases
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