Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.
Fluorescent glucose uptake probe
LXR inverse agonist that reduces glycolytic and lipogenic gene expression
Potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase
Inhibitor of glycerol-3-phosphate acyltransferase
A potent inhibitor of stearoyl-CoA desaturase 1
ATP citrate lyase (ACL) inhibitor
Potent and selective inhibitor of glutaminase (KGA and GAC)
Selective inhibitor of glutamate dehydrogenase 1(GDH1)
Potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD)
Pro-drug inhibitor of ornithine decarboxylase
Thiamet G is a potent and selective inhibitor of O-GlcNAcase
NGI-1 is a cell permeable inhibitor of oligosaccharyltransferase (OST)
Inhibits glycoprotein processing via inhibition of class I a-mannosidases