iPHF8 | Inhibitor of lysine demethylase PHF8
iPHF8 is a specific inhibitor (IC50 = 2.01 µM; EC50 = 2 µM in HeLa cells) of the human non-heme 2-oxoglutarate JmjC domain oxygenase/lysine demethylase PHF8.
Complex Carbohydrates
Lomitapide | Microsomal triglyceride transfer protein inhibitor
Lomitapide (182431-12-5) is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2
HC-258 | Covalent TEAD inhibitor
HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway. It was able to reduce gene expression levels
RECTAS | pre-mRNA splicing modulator
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells
JNK-IN-8 | Covalent JNK inhibitor
JNK-IN-8 (1410880-22-6) is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK blockade with JNK-IN-8 overcomes
