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Lipid metabolism and signaling

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  • Atglistatin | ATGL inhibitor
    Atglistatin (1469924-27-3) is the first small molecule inhibitor of adipose triglyceride lipase (ATGL) – IC50 = 700 nM.1  It exhibits high selectivity for ATGL, is active in vitro and in vivo, and does not inhibit...

  • Focus Biomolecules supplier, chemical structure of Cerulenin | Fatty Acid Synthase inhibitor | CAS 17397-89-6
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DU-14 | Sulfatase inhibitor | CAS 186303-55-9
    DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats1. Inhibits proliferation of human MCF-7 breast cancer cells2. References/Citations1) Johnson et al. (2000), The...

  • Enasidenib | Inhibitor of IDH2
    Enasidenib (1446502-114-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2)...

  • Fasnall HCl | Structure | Supplier
    A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in...

  • Fluvastatin Na | HMG CoA reductase inhibitor
    Potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1  Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2 Displays antineuroinflammatory...

  • FSG67 | GPAT inhibitor
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • GE-501516 | 317318-70-0 | Structure | Supplier
    GW-501516 (317318-70-0) is a potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1  Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of IPBT-5CA | GPR109B agonist | CAS 306935-41-1
    IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of JNJ-1661010 | FAAH inhibitor | CAS 681136-29-8
    JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure JZL-184 | MAG lipase inhibitor | CAS 1101854-58-3
    JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable. References/Citations1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces...

  • LY-2183240 | Anandamide uptake inhibitor
    LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2,3,4 to be an inhibitor of fatty acid amide hydrolase (FAAH) - IC50 = 14nM4,...

  • MF-438 | SCD1 inhibitor
    MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown...

  • Nonylbenzeneboronic acid | FAAH
    A potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes...

  • Orlistat | DAG Lipase-alpha inhibitor
    Orlistat (96829-58-2) is a lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-α1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PF-622 | FAAH inhibitor | CAS 898235-63-9
    PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable...

  • Focus Biomolecules supplier, chemical structure of PluriSln#1 | Stearoyl CoA desaturase inhibitor | CAS 91396-88-2
    PluriSln#1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln#1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure RHC-80267 | DAG Lipase inhibitor | CAS 83654-05-1
    RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic...

  • SR9243 | LXR inverse agonist
    SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types...

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