my account
  Loading... Please wait...


Sort by
  • Focus Biomolecules supplier, chemical structure of 680C91 | Tryptophan 2,3-dioxygenase inhibitor | CAS 163239-22-3
    680C91 (163239-22-3) is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM).1,2 Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BI-6015 | HNF4a inhibitor | CAS 93987-29-2
    BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to...

  • CBR-5884 |681159-27-3 | Structure | Supplier
    CBR-5884 (681159-27-3) is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells...

  • Indoximod | IDO modulator / tryptophan mimetic
    Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of IOX-1 | JMJD demethylase inhibitor | CAS 5852-78-8
    IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1 A broad...

  • Manumycin A | Farnesyltransferase inhibitor
    Manumycin A (52665-74-4) inhibits ras farnesyltransferase1 and prevents ras signaling2. Irreversibly inhibits neutral sphingomyelinase3. Abrogates IL-1β-induced HIF-1α activation in both glioma and non-glioma...

  • SR-8278 | 125944-66-5 | Structure | Supplier
    SR-8278 (125944-66-5) is an antagonist of the nuclear heme receptor, REV-ERB. Blocks the ability of the REV-ERBα agonist, GSK4112, to enhance REV-ERB-dependent repression in a cotransfection assay.1 Decreases glucagon...

  • Focus Biomolecules supplier, chemical structure of SR-9009 | RevErb alpha & beta agonist | CAS 1379686-30-2
    SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses...

  • Tolcapone | COMT inhibitor / TTR aggregation inhibitor
    Tolcapone (134308-13-7) is a catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus