Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts
BiochemicalTargets

CELLULAR METABOLISM

Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.

Complex carbohydrates

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Tunicamycin | ER stress inducer

CAS:
11089-65-9
Catalog Number:
10-2111
Activity:
ER stress inducer
Molecular Weight:
840.0 (Avg)
Molecular Formula:
C38H62N4O16 (tun. B)
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Glucose

Mito-lonidamine | Mitochondria-targeted antiglycolytic agent

Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown

CBR-470-1 | NRF2 signaling activator

CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Glutamine

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Gilteritinib | FLT3 Inhibitor

CAS:
1254053-43-4
Catalog Number:
10-4170
Activity:
FLT3 inhibitor
Chemical Names:
6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide; ASP2215
Molecular Weight:
552.72
Molecular Formula:
C29H44N8O3
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GAC Inhibitor 968 | Glutaminase C inhibitor

CAS:
311795-38-7
Catalog Number:
10-1538
Activity:
Glutaminase C inhibitor
Chemical Names:

5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one

Molecular Weight:
475.42
Molecular Formula:
C27H27BrN2O
Solubility:
Soluble in DMSO (up to 11 mg/ml) or in Ethanol (up to 1 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98%  TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Glutathione

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

DT-109 | Induces glutathione biosynthesis

CAS:
14857-82-0
Catalog Number:
10-5732
Activity:
Induces glutathione biosynthesis
Chemical Names:
Glycyl-glycyl-L-leucine; Gly-Gly-Leu-OH
Molecular Weight:
245.28
Molecular Formula:
C10H19N3O4
Solubility:
Soluble in DMSO (25 mg/ml with warming); Water (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

RSL3 | GPX4 inhibitor/Ferroptosis inducer

CAS:
1219810-16-8
Catalog Number:
10-3417
Activity:
GPX4 inhibitor/Ferroptosis inducer
Chemical Names:
(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Alternate Name:
1S,3R-RSL3
Molecular Weight:
440.88
Molecular Formula:
C23H21ClN2O5
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Kinases

UNC7467 | IP6K inhibitor

UNC7467 (2922283-43-8) is a potent inhibitor of inositol hexakisphosphate kinase (IP6K) – the isoform IP3K1 regulates metabolism, promotes insulin secretion from ß cells, attenuates certain aspects

CBR-470-1 | NRF2 signaling activator

CBR-470-1 (2416095-06-0) is an activator of NRF2 signaling (EC50 ~ 1 µM cellular ARE-LUC assay).1 It inhibits phosphoglycerate kinase 1 leading to a build-up of methylglyoxal which inactivates

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Lipid Metabolism

S07-2010 | pan-AKR1C inhibitor

S07-2010 (1223194-71-5) is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50’s for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Mitochondrial

Visomitin | Mitochondria-targeted antioxidant

Visomitin (934826-68-3) is a mitochondria-targeted antioxidant.1,2 A useful tool for studying mitochondrial oxidative stress involvement in many disease states.3-6 In clinical trials for the treatment of various eye

Mito-lonidamine | Mitochondria-targeted antiglycolytic agent

Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown

NAD

STF-118804 | NAMPT inhibitor

STF-118804 (894187-61-2) is a potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ biosynthesis from nicotinamide.1 It reduced the viability of most B-ALL cells

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

P7C3-A20 | NAMPT activator/Proneurogenic agent

CAS:
1235481-90-9
Catalog Number:
10-3414
Activity:
NAMPT activator/proneurogenic agent
Chemical Names:
3,6-Dibromo-ß-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
Molecular Weight:
506.21
Molecular Formula:
C22H19Br2FN2O
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Nucleotide

Raltitrexed | Thymidylate synthase inhibitor

Raltitrexed (112887-68-0) is an inhibitor of thymidylate synthase with significantly increased potency in many cancer cell lines when compared with 5-fluorouracil.1,2  It is also an inhibitor

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Polyamine

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

Mitoguazone 2HCl | Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor

CAS:
7059-23-6
Catalog Number:
10-4552
Activity:
Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
Alternate Names:
MGBG
Chemical Name:
Methylglyoxal bis(guanylhydrazone) dihydrochloride
Molecular Weight:
257.13
Molecular Formula:
C5H12N8 2HCl
Solubility:
Soluble in Water (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

POB | Ornithine decarboxylase inhibitor

CAS:
946135-39-3
Catalog Number:
10-4553
Activity:
Ornithine decarboxylase inhibitor
Chemical Name:
N-(4′-Pyridoxyl)-L-Ornithine(BOC)-Ome
Molecular Weight:
397.47
Molecular Formula:
C19H31N3O6
Solubility:
Soluble in DMSO (up to 25 mg/ml), in Water (up to 2 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in distilled water are not stable and must be made fresh and used within one working day.
Shipping Code:
RT

Sphingolipids

L-Cycloserine | Serine palmitoyltransferase inhibitor

L-Cycloserine (339-72-0) down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at

PF-543 HCl | Sphingosine kinase-1 inhibitor

PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

trans-Sulfuration

Intelliscreen™ Cancer Cell Metabolism Library

Catalog Number:
10-7101
Description:
171 modulators of various aspects of cancer cell metabolism.
Solubility:
DMSO or Water
Supplied As:
Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$4 600.00

PF-9366 | Methionine adenosyltransferase 2A inhibitor

CAS:
72882-78-1
Catalog Number:
10-4635
Activity:
Methionine adenosyltransferase 2A inhibitor
Chemical Name:
2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine
Molecular Weight:
350.85
Molecular Formula:
C20H19ClN4
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Propargylglycine | H2S synthase inhibitor

CAS:
64165-64-6
Catalog Number:
10-1366
Activity:
H2S synthase inhibitor
Chemical Name:
2-Amino-4-pentynoic acid
Molecular Weight:
113.12
Molecular Formula:
C5H7NO2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Other

Mirabegron | beta-3 Adrenergic agonist

Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and

S07-2010 | pan-AKR1C inhibitor

S07-2010 (1223194-71-5) is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50’s for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4

SM-88 | Tyrosine metabolism inhibitor

SM-88 (30625-05-9) is a “dysfunctional” tyrosine mimetic. It is taken up by cancer cells and disrupts tyrosine-mediated metabolic pathways including synthesis of the important protein mucin-1