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  • Focus Biomolecules cell signaling reagent supplier, Brefeldin A | Inhibits intracellular transport | CAS 20350-15-6
    Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable. References/Citations1)...

  • Focus Biomolecules, chemical structure Isofagomine tartrate | Glucocerebrosidase activator, chaperone | CAS 957230-65-8
    Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50 = 0.06 μM.1 Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2...

  • Manumycin A | Farnesyltransferase inhibitor
    Manumycin A (52665-74-4) inhibits ras farnesyltransferase1 and prevents ras signaling2. Irreversibly inhibits neutral sphingomyelinase3. Abrogates IL-1β-induced HIF-1α activation in both glioma and non-glioma...

  • Focus Biomolecules cell signaling supplier, chemical structure Miglustat HCl | Alpha-glucosidase inhibitor | CAS 210110-90-0
    Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of...

  • Focus Biomolecules supplier, chemical structure of Myriocin | Blocks sphingolipid biosynthesis | CAS 35891-70-4
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Perphenazine | Antipsychotic agent | CAS 58-39-9
    Perphenazine (58-39-9) is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of THI | Immunomodulator | CAS 94944-70-4
    THI (94944-70-4) was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering...

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