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Cellular Stress

Cellular responses to stress are important for cell survival and maintaining genomic stability. Signaling pathways and other systems activated in cellular stress include heat shock, ubiquitin-proteasome, DNA damage response, inflammasome, unfolded protein response, NFκB, ERK/JNK/p38 MAPK, and Keap1-Nrf2 among others. While these responses may be beneficial for normal cells, they can be co-opted in pathological states such as cancer to the detriment of the organism.

View All Cellular Stress Reagents

DNA damage

  • Rucaparib phosphate

    Rucaparib is a potent PARP1 inhibitor

  • RI-1

    RI-1 is a selective inhibitor of RAD51

  • Lomeguatrib

    Lomeguatrib is a potent inhibitor of the DNA methyltransferase MGMT

  • Mirin

    Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex

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Reactive oxygen species

  • Bakuchiol

    Bakuchiol is a natural terpenoid antioxidant

  • Carnosic acid

    Carnosic acid is an antioxidant and free radical scavenger

  • DMNQ

    DMNQ is non-alkylating redox cycling quinone useful for studying ROS and oxidative stress

  • L-Ergothioneine

    L-Ergothioneine is an endogenous antioxidant

View All Reactive oxygen species Reagents

Heat shock proteins

  • Radicicol

    Inhibits HSP90 by binding to the ATP-binding pocket

  • 17-DMAG

    17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines

  • Teprenone

    Teprenone is an inducer of HSP70

  • Compound 115-7c

    Artificial co-chaperone for HSP70

View All Heat shock protein Reagents

Unfolded protein response

  • Azoramide

    Azoramide improve ER folding and activates ER chaperone capacity

  • Toyocamycin

    Toyocamycin inhibits the unfolded protein response

  • 4m8C

    Inhibits the unfolded protein response via inhibition of IRE1 ribonuclease

  • STF-083010

    STF-083010 inhibits IRE1 endonuclease activity

View All Unfolded protein response Reagents


  • 3-Methyladenine

    Inhibits autophagy by blocking autophagosome formation

  • Bafilomycin A1

    Bafilomycin A1 inhibits autophagy by disrupting the fusion between autophagosomes and lysosomes

  • Seriniquinone

    Induces autophagy via targeting of dermicidin

  • Ophiobolin A

    Ophiobolin A is a natural product that induces autophagy

  • SMER-28

    SMER-28 induces autophagy by an mTOR-independent pathway

View All Autophagy Reagents

ER Stress


    TUDCA is a classic inhibitor of ER stress

  • Patulin

    Patulin induces apoptosis through an ROS-mediated ER stress pathway

  • Tunicamycin

    Tunicamycin causes ER stress-induced autophagy

  • Salubrinal

    Salubrinal is an eIF2a phosphatase inhibitor that mitigates ER stress

View All ER Stress Reagents