my account
Login
  Loading... Please wait...

Cellular Stress

Cellular responses to stress are important for cell survival and maintaining genomic stability. Signaling pathways and other systems activated in cellular stress include heat shock, ubiquitin-proteasome, DNA damage response, inflammasome, unfolded protein response, NFκB, ERK/JNK/p38 MAPK, and Keap1-Nrf2 among others. While these responses may be beneficial for normal cells, they can be co-opted in pathological states such as cancer to the detriment of the organism.

View All Cellular Stress Reagents

DNA damage

  • Rucaparib phosphate

    Rucaparib is a potent PARP1 inhibitor

  • RI-1

    RI-1 is a selective inhibitor of RAD51

  • Lomeguatrib

    Lomeguatrib is a potent inhibitor of the DNA methyltransferase MGMT

  • Mirin

    Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex

View All DNA damage Reagents

Reactive oxygen species

  • Bakuchiol

    Bakuchiol is a natural terpenoid antioxidant

  • Carnosic acid

    Carnosic acid is an antioxidant and free radical scavenger

  • DMNQ

    DMNQ is non-alkylating redox cycling quinone useful for studying ROS and oxidative stress

  • L-Ergothioneine

    L-Ergothioneine is an endogenous antioxidant

View All Reactive oxygen species Reagents

Heat shock proteins

  • Radicicol

    Inhibits HSP90 by binding to the ATP-binding pocket

  • 17-DMAG

    17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines

  • Teprenone

    Teprenone is an inducer of HSP70

  • Compound 115-7c

    Artificial co-chaperone for HSP70

View All Heat shock protein Reagents

Unfolded protein response

  • Azoramide

    Azoramide improve ER folding and activates ER chaperone capacity

  • Toyocamycin

    Toyocamycin inhibits the unfolded protein response

  • 4m8C

    Inhibits the unfolded protein response via inhibition of IRE1 ribonuclease

  • STF-083010

    STF-083010 inhibits IRE1 endonuclease activity

View All Unfolded protein response Reagents

Autophagy

  • 3-Methyladenine

    Inhibits autophagy by blocking autophagosome formation

  • Bafilomycin A1

    Bafilomycin A1 inhibits autophagy by disrupting the fusion between autophagosomes and lysosomes

  • Seriniquinone

    Induces autophagy via targeting of dermicidin

  • Ophiobolin A

    Ophiobolin A is a natural product that induces autophagy

  • SMER-28

    SMER-28 induces autophagy by an mTOR-independent pathway

View All Autophagy Reagents

ER Stress

  • TUDCA

    TUDCA is a classic inhibitor of ER stress

  • Patulin

    Patulin induces apoptosis through an ROS-mediated ER stress pathway

  • Tunicamycin

    Tunicamycin causes ER stress-induced autophagy

  • Salubrinal

    Salubrinal is an eIF2a phosphatase inhibitor that mitigates ER stress

View All ER Stress Reagents

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus