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Cellular Stress

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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    $70.00
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

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  • Focus Biomolecules reagent supplier, chemical structure of 1,4-DPCA | Prolyl hydroxylase inhibitor | CAS 331830-20-7
    1,4-DPCA | Prolyl hydroxylase inhibitor
    $60.00
    1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 17-AAG | HSP90 inhibitor | CAS 75747-14-7
    17-AAG | HSP90 inhibitor
    $28.00
    17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable...

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  • 17-AHA-Geldanamycin | Structure | Supplier
    17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand
    $100.00
    17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 17-DMAG | HSP90 inhibitor | CAS 150270-08-9
    17-DMAG | HSP90 inhibitor
    $50.00
    17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 17-GMP-APA-GA | Modified Geldanamycin
    17-GMP-APA-GA | Modified Geldanamycin
    $185.00
    17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example. References/Citations1) Mandler et al. (2004),...

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  • 17-PAAG | Structure | Supplier
    17-PAAG | Propargyl geldanamycin
    $55.00
    17-PAAG is a semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactive molecules such as steroids via click chemistry.1 Chemical modifications at...

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  • Focus Biomolecules cell signaling supplier, chemical structure of 3-Methyladenine | Autophagosome inhibitor | CAS 5142-23-4
    3-Methyladenine | Autophagosome inhibitor
    $30.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure 4μ8C | IRE1 ribonuclease inhibitor | CAS 14003-96-4
    4μ8C | IRE1 ribonuclease inhibitor
    $75.00
    4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of...

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  • Focus Biomolecules cell signaling tech supplier, structure 5-Fluorouracil | Inhibitor of thymidylate synthase | CAS 51-21-8
    5-Fluorouracil | Inhibitor of thymidylate synthase
    $20.00
    5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP),...

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  • Focus Biomolecules supplier, chemical structure of 8-Oxo-2'-deoxyguanosine | Marker for DNA damage | CAS 88847-89-6
    8-Oxo-2'-deoxyguanosine | Marker for DNA damage
    $38.00
    8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes1. It is a critical biomarker for oxidative stress and carcinogenesis2,3. References/Citations1) Beckman et al...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AICAR | AMPK activator | CAS 2627-69-2
    AICAR | AMPK activator
    $30.00
    Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Amifostine | Cellular protectant | CAS 20537-88-6
    Amifostine | Cellular protectant
    $56.00
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.2-4...

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  • Anacardic Acid | HAT inhibitor
    Anacardic Acid | HAT inhibitor
    $35.00
    Anacardic acid (16611-84-0) is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 µM respectively).1 Anacardic acid sensitizes...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    Apicidin | HDAC inhibitor
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin | Protein kinase inhibitor
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

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  • Artesunate | Kills cancer stem cells / Depolarizes mitochondria
    Artesunate | Kills cancer stem cells / Depolarizes mitochondria
    $45.00
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

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  • Azoramide | UPR modulator
    Azoramide | UPR modulator
    $50.00
    Azoramide (932986-18-0) is a modulator of the unfolded protein response (UPR).1  It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-277 | CHK2 inhibitor | CAS 516480-79-8
    BML-277 | CHK2 inhibitor
    $90.00
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

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  • C22 Ceramide | Structure | supplier
    C22 Ceramide | MCSR inhibitor
    $55.00
    C22 Ceramide is a  long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids...

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