Cellular Stress
Autophagy DNA Damage ER Stress HSP HIF mTOR p53 Programmed cell death ROS Ubiquitin Proteasome UPR NF-kB Heat Shock Other
Showing 1–12 of 154 results
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Bone and Connective Tissue
1,4-DPCA | Prolyl hydroxylase inhibitor
1,4-DPCA (331830-20-7) is a potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM).1 Inhibits collagen deposition via inhibition of collagen prolin...$60.00 – $220.00 Select options -
Angiogenesis
17-AAG | HSP90 inhibitor
17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and...$30.00 – $68.00 Select options -
Cellular Stress
17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand
17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively...$100.00 – $400.00 Select options -
Angiogenesis
17-DMAG | HSP90 inhibitor
17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and in...$30.00 – $68.00 Select options -
Cancer
17-GMP-APA-GA | Modified Geldanamycin
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immun...$140.00 – $500.00 Select options -
Cellular Stress
17-PAAG | Propargyl geldanamycin click reagent
17-PAAG is a semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactiv...$55.00 – $130.00 Select options -
New Products
2-AAPA | Glutathione/thioredoxin reductase inhibitor
2-AAPA (1133387-90-2) inhibits glutathione reductase and thioredoxin reductase,IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial functio...$60.00 – $240.00 Select options -
Autophagy
3-Methyladenine | Autophagosome inhibitor
3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K...$30.00 – $90.00 Select options -
Cellular Stress
4µ8C | IRE1 ribonuclease inhibitor
4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonu...$30.00 – $94.00 Select options -
Cancer
5-Fluorouracil | Inhibitor of thymidylate synthase
5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metaboli...$20.00 – $40.00 Select options -
Cancer
8-Oxo-2′-deoxyguanosine | Marker for DNA damage
8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1 It is a critical biomarker for oxidat...$38.00 – $160.00 Select options -
Cardioprotection
AA147 | ATF6 activator
AA147 (393121-74-9) is a preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellul...$70.00 – $275.00 Select options
