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PhysioProcesses

Cellular Stress

Cellular responses to stress are important for cell survival and maintaining genomic stability. Signaling pathways and other systems activated in cellular stress include heat shock, ubiquitin-proteasome, DNA damage response, inflammasome, unfolded protein response, NFκB, ERK/JNK/p38 MAPK, and Keap1-Nrf2 among others. While these responses may be beneficial for normal cells, they can be co-opted in pathological states such as cancer to the detriment of the organism.

Autophagy

Vacuolin-1 | Autophagy/PIKfyve inhibitor

Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on

AR7 | Activates chaperone mediated autophagy

CAS:
80306-38-3
Catalog Number:
10-5515
Activity:
Activates chaperone mediated autophagy
Chemical Names:
7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
Molecular Weight:
257.72
Molecular Formula:
C15H12ClNO
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Pale pink solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

R-59022 | DAG kinase inhibitor

CAS:
93076-89-2
Catalog Number:
10-3579
Activity:
SGLT2 inhibitor
Chemical Names:
6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Molecular Weight:
459.58
Molecular Formula:
C27H26FN3OS
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DNA Damage Response

TH10785 | OGG1 activator

TH10785 (1002801-51-5) is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for

VE-821 | Potent and selective ATR inhibitor

CAS:
1232410-49-9
Catalog Number:
10-5589
Activity:
ATR inhibitor
Chemical Names:
3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
Molecular Weight:
368.41
Molecular Formula:
C18H16N4O3S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

SU0268 | OGG1 inhibitor

CAS:
2210228-45-6
Catalog Number:
10-4700
Activity:
OGG1 Inhibitor
Chemical Names:
3-[4-[[1-(Cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide
Molecular Weight:
475.56
Molecular Formula:
C26H25N3O4S
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

ER Stress

C-DIM 8 | Nur77 Antagonist

CAS:
151358-47-3
Catalog Number:
10-5157
Activity:
Nur77 antagonist
Chemical Names:
1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane
Alternate Name:
DIM-C-pPhOH
Molecular Weight:
338.41
Molecular Formula:
C23H18N2O
Solubility:
Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
Physical Properties:
Pink solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Ceapin-A7 | ATF6α/UPR inhibitor

CAS:
2323027-38-7
Catalog Number:
10-3974
Activity:
ATF6α/UPR inhibitor
Chemical Names:
N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
Molecular Weight:
470.33
Molecular Formula:
C20H12F6N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AA147 | ATF6 activator

CAS:
393121-74-9
Catalog Number:
10-3973
Activity:
Activator of ER stress sensing protein ATF6
Chemical Names:
N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide; Compound 147
Molecular Weight:
255.32
Molecular Formula:
C16H17NO2
Solubility:
Soluble in DMSO (>25 mg/ml); ethanol (>25 mg/mL)
Physical Properties:
Beige to pale orange solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

HSP

BGP-15 | Cellular protectant

CAS:
66611-37-8
Catalog Number:
10-1373
Activity:
Cellular protectant
Chemical Names:
N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
Molecular Weight:
351.28
Molecular Formula:
C14H22N4O2·2HCl
Solubility:
Soluble in Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
Shipping Code:
RT

KNK437 | HSP70 inhibitor

CAS:
218924-25-5
Catalog Number:
10-5561
Activity:
HSP70 inhibitor
Chemical Names:
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Molecular Weight:
245.23
Molecular Formula:
C13H11NO4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

BIIB021 | HSP90 Inhibitor

CAS:
848695-25-0
Catalog Number:
10-4641
Activity:
Potent HSP90 inhibitor
Chemical Names:
6-Chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine; CNF2024
Molecular Weight:
318.76
Molecular Formula:
C14H15ClN6O
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
Shipping Code:
RT

Hypoxia

Roxadustat | Proyl hydroxylase domain inhibitor / HIF stabilizer

CAS:
808118-40-3
Catalog Number:
10-4468
Activity:
Proyl hydroxylase domain inhibitor / HIF stabilizer
Chemical Name:
2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Alternate Name:
FG-4592
Molecular Weight:
352.35
Molecular Formula:
C19H16N2O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Off-white or white solid
Purity:
99% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

YC-1 | Soluble guanylyl cyclase activator

CAS:
170632-47-0
Catalog Number:
10-1581
Activity:
Soluble guanylyl cyclase activator
Chemical Name:
3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
Alternate Name:
Lificiguat
Molecular Weight:
304.34
Molecular Formula:
C19H16N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Pink solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor

CAS:
1227158-85-1
Catalog Number:
10-4910
Activity:
HIF-1 / Mitochondrial complex I inhibitor
Chemical Name:
5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
Molecular Weight:
525.54
Molecular Formula:
C26H26F3N7O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Oxidative Stress

Lipoic acid | Endogenous antioxidant and cofactor

alpha-Lipoic acid (1077-28-7) is an endogenous antioxidant.1,2 Treatment with alpha-lipoic acid increased hepatic nuclear Nrf2 levels, induced Nrf2-mediated gene transcription, and reversed age-related decline in hepatic

HET0016 | 20-HETE biosynthesis inhibitor

HET0016 (339068-25-6) inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC50=8.9 nM in human renal microsomes).1 It displays

Ubiquitin proteasome