DNA Damage
Showing 1–12 of 15 results
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Cancer
5-Fluorouracil | Inhibitor of thymidylate synthase
5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metaboli...$20.00 – $40.00 Select options -
Cell Cycle
BML-277 | CHK2 inhibitor
BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows le...$90.00 – $360.00 Select options -
Apoptosis
Camptothecin | Topoisomerase I inhibitor
Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase ...$30.00 – $200.00 Select options -
Apoptosis
Doxorubicin HCl | DNA damaging agent
Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl i...$45.00 – $95.00 Select options -
Approved Drugs
Epirubicin HCl | DNA damaging agent
Epirubicin HCl (56390-09-1) is an antitumor agent.1 Inhibits topoisomerase II.2 Induces DNA damage by a number of different mechanisms including in...$48.00 – $190.00 Select options -
Approved Drugs
Etoposide | Topoisomerase II inhibitor
Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strand...$45.00 – $145.00 Select options -
Angiogenesis
Fascaplysin | CDK4 inhibitor
Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent ki...$40.00 – $160.00 Select options -
Cellular Stress
GPI-16552 | PARG inhibitor
GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/...$60.00 – $240.00 Select options -
ADP-ribosylation
ME-0328 | PARP3 inhibitor
ME-0328 (1445251-22-8) is a potent and selective PARP3 inhibitor (IC50=0.89 μM). Selective over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10...$75.00 – $300.00 Select options -
Cell Cycle
Mirin | Mre11-Rad50-Nbs1 inhibitor
Mirin (299953-00-7) is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 μM for inhibition of ATM activity), part of the MRN-ATM(ataxia-...$50.00 – $200.00 Select options -
Apoptosis
Mitomycin C | DNA crosslinking and damaging agent
Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approv...$45.00 – $160.00 Select options -
Cell Cycle
PJ-34 HCl | PARP1,2 inhibitor
PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM1. Reduces ischemia reperfusion injury in a mouse model.2 D...$56.00 – $136.00 Select options
