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BiochemicalTargets

DNA Damage/Repair

The dysregulation of the balance of DNA damage and repair leads to genomic mutation and is primary to tumor development and progression. It can also be involved in neurodegeneration and inflammation. The balance can be perturbed by mutagens, radiation, inherited mutations, inflammation, and cell cycle disruption. Many small molecule reagents are available that can either cause DNA damage or modulate the DNA repair response.

Alkylation

2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor

CAS:
10356-76-0
Catalog Number:
10-2685
Activity:
Irreversible DNA methyl transferase inhibitor
Alternate Names:
FCDR; NSC-48006; FdCyd
Chemical Name:
5-Fluoro-2’deoxycytidine
Molecular Weight:
245.21
Molecular Formula:
C9H12FN3O4
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Mitomycin C | DNA crosslinking and damaging agent

CAS:
50-07-7
Catalog Number:
10-1170
Activity:
DNA crosslinking and damaging agent
Chemical Name:
Natural fermentation product from Streptomyces sp.
Molecular Weight:
334.33
Molecular Formula:
C15H18N4O5
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Water (up to 1 mg/ml).
Physical Properties:
Blue-violet solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Storing aqueous solutions is not recommended.
Shipping Code:
RT

ATM/ATR

VE-821 | Potent and selective ATR inhibitor

CAS:
1232410-49-9
Catalog Number:
10-5589
Activity:
ATR inhibitor
Chemical Names:
3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
Molecular Weight:
368.41
Molecular Formula:
C18H16N4O3S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Beige solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

AZ20 | ATR kinase inhibitor

CAS:
1233339-22-4
Catalog Number:
10-4675
Activity:
ATR kinase inhibitor
Chemical Name:
4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole
Molecular Weight:
412.51
Molecular Formula:
C21H24N4O3S
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

KU-55933 | ATM Kinase Inhibitor

CAS:
587871-26-9
Catalog Number:
10-1518
Activity:
ATM Kinase Inhibitor
Chemical Name:
2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Molecular Weight:
395.5
Molecular Formula:
C21H17NO3S2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Cell cycle checkpoints

Adavosertib | Wee1 kinase inhibitor

CAS:
955365-80-7
Catalog Number:
10-4823
Activity:
Wee1 kinase inhibitor
Chemical Names:
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
Alternate Name:
MK-1775; AZD1775
Molecular Weight:
500.61
Molecular Formula:
C27H32N8O2
Solubility:
Soluble in DMSO (70 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AZD7762 | Checkpoint kinase 1/2 inhibitor

CAS:
860352-01-8 (free base)
Catalog Number:
10-4771
Activity:
Checkpoint kinase 1/2 inhibitor
Chemical Name:
3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochloride
Molecular Weight:
398.88
Molecular Formula:
C17H19FN4O2S • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Yellow or brown solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

LY2603618 | Potent and selective Chk1 inhibitor

CAS:
911222-45-2
Catalog Number:
10-4123
Activity:
Potent and selective Chk1 inhibitor
Chemical Name:
N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N’-(5-methyl-2-pyrazinyl)urea
Alternate Names:
Rabusertib
Molecular Weight:
436.30
Molecular Formula:
C18H22BrN5O3
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DNA repair

SU0268 | OGG1 inhibitor

CAS:
2210228-45-6
Catalog Number:
10-4700
Activity:
OGG1 Inhibitor
Chemical Names:
3-[4-[[1-(Cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide
Molecular Weight:
475.56
Molecular Formula:
C26H25N3O4S
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

LNT 1 | FEN1 Inhibitor

CAS:
824983-91-7
Catalog Number:
10-4036
Activity:
FEN1 inhibitor
Chemical Names:
1-(2,3-Dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione; FEN1-IN-1
Molecular Weight:
332.33
Molecular Formula:
C15H12N2O5S
Solubility:
Soluble in DMSO (15 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

RK-33 | DDX3 inhibitor

CAS:
1070773-09-9
Catalog Number:
10-4839
Activity:
DDX3 inhibitor
Chemical Name:
3,7-Bis(4-methoxybenzyl)-3,7-dihydro-1,3,4,6,7,9-hexaza-2H-cyclopenta[e]azulene-2-one
Molecular Weight:
428.44
Molecular Formula:
C23H40N6O3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

DNA-PK

NU7441 | DNA-PK inhibitor

CAS:
503468-95-9
Catalog Number:
10-4810
Activity:
DNA-PK inhibitor
Chemical Name:
8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
Alternate Name:
Ku-57788
Molecular Weight:
413.49
Molecular Formula:
C25H19NO3S
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming).
Physical Properties:
Off-white to beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Intercalation

Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent

CAS:
23541-50-6
Catalog Number:
10-2429
Activity:
DNA Damaging Agent / Anticancer agent
Alternate Names:
Daunomycin; rubidomycin; RP-13057
Molecular Weight:
536.98
Molecular Formula:
C27H39NO10 • HCl
Solubility:
Soluble in water (up to 25 mg/ml)
Physical Properties:
Red solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Epirubicin HCl | DNA damaging agent

CAS:
56390-09-1
Catalog Number:
10-2761
Activity:
DNA damaging agent
Chemical Name:
4′-Epidoxorubicin
Molecular Weight:
579.99
Molecular Formula:
C27H29NO11 HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).
Physical Properties:
Red orange solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Doxorubicin HCl | DNA damaging agent

CAS:
25316-40-9
Catalog Number:
10-2130
Activity:
DNA damaging agent
Alternate Names:
Adriamycin; NSC-123127
Molecular Weight:
579.99
Molecular Formula:
C27H29NO11 HCl
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
Red-orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Markers

Chromomycin A3 | DNA Stain

CAS:
7059-24-7
Catalog Number:
10-2064
Activity:
DNA stain
Chemical Names:
Aburamycin B; CMA3; NSC-58514
Molecular Weight:
1183.25
Molecular Formula:
C57H82O26
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

8-Oxo-2′-deoxyguanosine | Marker for DNA damage

CAS:
88847-89-6
Catalog Number:
10-2690
Activity:
Marker for DNA damage
Alternate Names:
8-Oxo-dG; Oxo-dG
Chemical Name:
8-Oxo-7,8-dihydro-2′-deoxyguanosine
Molecular Weight:
283.25
Molecular Formula:
C10H13N5O5
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Oxidation

TH10785 | OGG1 activator

TH10785 (1002801-51-5) is an 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for

Ochratoxin A | Mycotoxin

Ochratoxin A (303-47-9) is a mycotoxin that causes widespread contamination in foodstuffs and environments thus causing health risks to humans and animals.1 It has been shown to

Bleomycin sulfate | Induces double strand DNA breaks

CAS:
9041-93-4
Catalog Number:
10-2623
Activity:
Fibrosis-inducing agent
Source:
From Streptomyces verticillus
Molecular Weight:
1512.62
Molecular Formula:
C55H85N17O25S4
Solubility:
Soluble in Water (up to 20 mg/ml)
Physical Properties:
White or off-white solid
Purity:
Contains a mixture of A2 (~70%) and B2 (~30%) forms
95% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

p53

SR1078 | ROR agonist

SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome

PARG

GPI-16552 | PARG inhibitor

CAS:
443794-40-9
Catalog Number:
10-1502
Activity:
PARG inhibitor
Chemical Name:
N-bis-(3-Phenyl-propyl)-9-oxo-fluorene-2,7-diamide
Molecular Weight:
502.62
Molecular Formula:
C33H30N2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Shipping Code:
RT

PARP

Veliparib 2HCl | PARP 1/2 inhibitor

CAS:
912445-05-7
Catalog Number:
10-2419
Activity:
PARP 1/2 inhibitor
Chemical Names:
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide dihydrochloride
Alternate Name:
ABT-888
Molecular Weight:
317.22
Molecular Formula:
C13H16N4O·2HCl
Solubility:
Soluble in DMSO (30 mg/ml); water (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

BGP-15 | Cellular protectant

CAS:
66611-37-8
Catalog Number:
10-1373
Activity:
Cellular protectant
Chemical Names:
N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
Molecular Weight:
351.28
Molecular Formula:
C14H22N4O2·2HCl
Solubility:
Soluble in Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
Shipping Code:
RT

Cordycepin | AMPK activator

CAS:
73-03-0
Catalog Number:
10-2408
Activity:
AMPK activator
Chemical Name:
3’-Deoxyadenosine
Alternate Name:
NSC 63984
Molecular Weight:
251.24
Molecular Formula:
C10H13N5O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% byHPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Topoisomerase

ß-Lapachone | Topoisomerase-1 inhibitor

CAS:
4707-32-8
Catalog Number:
10-2386
Activity:
Topoisomerase I inhibitor
Chemical Name:
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Alternate Name:
NSC-26326
Molecular Formula:
C15H14O3
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Epirubicin HCl | DNA damaging agent

CAS:
56390-09-1
Catalog Number:
10-2761
Activity:
DNA damaging agent
Chemical Name:
4′-Epidoxorubicin
Molecular Weight:
579.99
Molecular Formula:
C27H29NO11 HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 5 mg/ml).
Physical Properties:
Red orange solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

SN-38 | DNA topoisomerase I inhibitor

CAS:
86639-52-3
Catalog Number:
10-2425
Activity:
DNA topoisomerase I inhibitor
Chemical Name:
7-Ethyl-10-hydroxycamptothecin
Molecular Weight:
392.41
Molecular Formula:
C22H20N2O5
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Other

AOH1996 | PCNA inhibitor

AOH1996 (2089314-64-5) inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1  It enhances the interaction between PCNA and RPB1 subunit

PF-543 HCl | Sphingosine kinase-1 inhibitor

PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous

Ochratoxin A | Mycotoxin

Ochratoxin A (303-47-9) is a mycotoxin that causes widespread contamination in foodstuffs and environments thus causing health risks to humans and animals.1 It has been shown to