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p53

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  • Amifostine | Cellular protectant
    $56.00
    Amifostine (20537-88-6) is a broad sprectrun radio- and chemoprotective agent.1 Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants...

  • Focus Biomolecules supplier, chemical structure of Cytochalasin D | Disrupts actin filaments | CAS 22144-77-0
    $63.00
    Cytochalasin D (22144-77-0) is a potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across...

  • DMOG | Inhibits prolyl hydroxylase domain-containing proteins
    $60.00
    DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of EX-527 | SIRT1 inhibitor | CAS 49643-96-3
    $70.00
    EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable. References/Citations1) Solomon et al...

  • Focus Biomolecules supplier, chemical structure of Leptomycin B | Nuclear export inhibitor | CAS 87081-35-4
    $60.00
    Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-11. Inhibits the nuclear export of the HIV regulatory protein Rev2. Leptomycin B stabilizes...

  • Focus Biomolecules supplier, chemical structure of Myriocin | Blocks sphingolipid biosynthesis | CAS 35891-70-4
    $65.00
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of NSC-66811 | p53/mdm2 inhibitor | CAS 6964-62-1
    $100.00
    NSC-66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable...

  • NSC59984 | p53 activator
    $50.00
    NSC59984 (803647-40-7) is a p53 activator.  Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Nutlin-3 | p53/mdm2 inhibitor | CAS 548472-68-0
    $100.00
    Nutlin-3 (548472-68-0) is an MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p531. Nutlin-3 displays antiproliferative activity and induces apoptosis in a variety of tumor cells.2-4...

  • Pifithrin alpha | p53 inhibitor
    $50.00
    Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Pifithrin mu | Hsp70 inhibitor | CAS 64984-31-2
    $35.00
    Pifithrin μ (64984-31-2) selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. Inhibits p53 binding to antiapoptotic proteins Bcl-xL and Bcl-2. Pifithrin μ rescues...

  • PRIMA-1(MET) | Reactivates mutant p53
    $60.00
    PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SL-01 | p53/mdm2 inhibitor | AS 26049-94-5
    $45.00
    SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ. References/Citations1) Li et al. (2011), A cell-based high-throughput assay for the screening of...

  • UNC0379 | Selective SETD8 inhibitor
    $65.00
    UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an MCE assay. UNC0379...

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