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Programmed Cell Death

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  • Chaetocin | Lys methyltransferase inhibitor
    $70.00
    Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methtransferase1. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and...

  • Emelin | 550-24-3 | Structure | Supplier
    $50.00
    Embelin (550-24-3) inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. ...

  • Erastin | Ferroptosis inducer
    $60.00
    Erastin (571203-78-6) is a ferroptosis inducer.1 Inhibits the cystine-glutamate antiporter, system Xc- leading to activation of an ER stress response.2 Inhibition of system Xc- leads to cysteine starvation, glutathione...

  • Lenalidomide | Immunomodulator
    $50.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • Ophiobolin A | Autophagy inducer / Anticancer
    $60.00
    Ophiobolin A (4611-05-6) selectively inhibits the growth of cancer cells (IC50=0.4-4.3 μM) over normal cells (IC50=20.9 μM).1 Induces non-apoptotic cell death in glioblastoma cells and is active in an in vivo model.2...

  • Patulin | Oxidative- and ER-stress inducer
    $44.00
    Patulin (149-29-1) is a mycotoxin found in contaminated fruits.  Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to...

  • Purvalanol A | CDK inhibitor
    $50.00
    Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests...

  • Salinomycin Na | Cancer stem cell inhibitor
    $48.00
    Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma...

  • Swainsonine | Glycosidase inhibitor
    $70.00
    Swainsonine (72741-87-8) is a naturally occurring alkaloidal toxin found in locoweed. Inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II (IC50 = 0.2 mM).1 Inhibits growth and potentiates...

  • Tamoxifen citrate | 54965-24-1 | Structure | Supplier
    $30.00
    Tamoxifen citrate (54965-24-1) is an estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines1. Displays neuroprotective effects in permanent focal...

  • Toyocamycin | Unfolded protein response (UPR) inhibitor
    $70.00
    Toyocamycin (606-58-6) is an adenosine analog which inhibits ribozyme self cleavage in mammalian cells, EC50 = 0.4 μM (for expression of a luciferase reporter).1 A potent inhibitor of ER stress-induced XBP1 mRNA splicing...

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