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ROS

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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    $70.00
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Artesunate | Kills cancer stem cells | CAS 88495-63-0
    $45.00
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

  • Auraptene | Neuroprotective / Neuritogenic agent
    $30.00
    Auraptene (495-02-3) is a bioactive terpenoid occurring in a variety of citrus fruits and possessing therapeutic potential.1   Displays neuritogenic activity2 and neuroprotective effects via suppression of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CHS-828 | NAMPT inhibitor | CAS 200484-11-3
    $50.00
    CHS-828 (200484-11-3) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Clozapine | Dopamine D2/D4 antagonist | CAS 5786-21-0
    $30.00
    Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7...

  • Dp44mT | Metal chelator
    $25.00
    Dp44mT (152095-12-0) is a metal chelator with potent antitumor activity.1,2 It displayed an average IC50 of 30 nM over 28 cancer cell lines (IC50 range was 5 nM to 400 nM).2 Dp44mT retained its antiproliferative activity in...

  • Focus Biomolecules cell signaling supplier, chemical structure of L-Ergothioneine | Antioxidant - endogenous | CAS 497-30-3
    $48.00
    L-Ergothioneine (CAS 497-30-3) is a naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM.1 Rescues PC12 cells from β-amyloid-induced apoptotic cell death...

  • Focus Biomolecules reagent supplier, chemical structure of Mito-TEMPO | Mitochondria targeted antioxidant | CAS 1334850-99-5
    $55.00
    Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1 Resolves...

  • Focus Biomolecules cell signaling supplier, chemical structure of Patulin | Oxidative- and ER-stress inducer | CAS 149-29-1
    $44.00
    Patulin (149-29-1) is a mycotoxin found in contaminated fruits.  Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to...

  • PRIMA-1(MET) | Reactivates mutant p53
    $50.00
    PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma...

  • TEMPOL | SOD mimetic
    $48.00
    TEMPOL (2226-96-2) is a superoxide dismutase (SOD) mimetic. Displays protective effects in CNS1 kidney2 and radiation damage3. Inhibits superoxide anion-induced inflammatory pain in mice.4 Blunts diabetes-induced...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trolox | Antioxidant | CAS 53188-07-1
    $25.00
    Trolox (53188-07-1) is a water soluble derivative of vitamin E with potent antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Inhibits peroxynitrite-mediated...

  • Focus Biomolecules cell signaling supplier, chemical structure of TTFA | Mitochondrial Complex II inhibitor | CAS 326-91-0
    $25.00
    TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp...

  • Focus Biomolecules cell signaling reagent supplier, VAS 2870 | Nox inhibitor | CAS 722456-31-7
    $55.00
    VAS-2870 (722456-31-7) is a NAD(P)H oxidase (Nox) inhibitor. Abolishes PDGF-mediated Nox activation and ROS production (100% at 10 μM). Inhibits PMA-induced oxidative burst in HL-60 cells (IC50=2 μM). VAS-2870 enhances...