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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

  • Artesunate | Kills cancer stem cells / Depolarizes mitochondria
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

  • CHS-828 | NAMPT inhibitor
    CHS-828 (200484-11-3) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent...

  • Clozapine | 5786-21-0 | Structure | Supplier
    Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7...

  • L-Ergothioneine | Antioxidant - endogenous
    Naturally occurring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM.1 Rescues PC12 cells from b-amyloid-induced apoptotic cell death.2 Protects against cisplatin-induced neuronal...

  • Mito-TEMPO | Mitochondria targeted antioxidant
    Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1 Resolves...

  • Patulin | Oxidative- and ER-stress inducer
    Patulin (149-29-1) is a mycotoxin found in contaminated fruits.  Increases ROS generation and oxidative stress in cells which is mediated by p53.1 Displays cytotoxic effects on a variety of cell lines.2 Causes damage to...

  • PRIMA-1(MET) | Reactivates mutant p53
    PRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in...

  • TEMPOL | SOD mimetic
    TEMPOL (2226-96-2) is a superoxide dismutase (SOD) mimetic. Displays protective effects in CNS1 kidney2 and radiation damage3. Inhibits superoxide anion-induced inflammatory pain in mice.4 Blunts diabetes-induced...

  • Trolox | Antioxidant
    Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities1. Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells2. Trolox inhibits peroxynitrite-mediated...

  • TTFA | Mitochondrial Complex II inhibitor
    TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp...

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