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Cellular Trafficking

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  • Focus Biomolecules reagent supplier, chemical structure of 2-Bromopalmitic acid | Palmitoylation inhibitor | CAS 18263-25-7
    $40.00
    2-Bromopalmitic acid (18263-25-7) inhibits protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential...

  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    $50.00
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • Focus Biomolecules cell signaling reagent supplier, Brefeldin A | Inhibits intracellular transport | CAS 20350-15-6
    $30.00
    Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable. References/Citations1)...

  • Focus Biomolecules, chemical structure CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase | CAS 166981-13-1
    $125.00
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Dynasore | Dynamin inhibitor |  CAS 304448-55-3
    $40.00
    Dynasore (304448-55-3) is a noncompetitive inhibitor of dynamin GTPase activity and blocks dynamin-dependent endocytosis in cells, including neurons. It inhibits the GTPase activity of dynamin1, dynamin2, and Drp1...

  • Focus Biomolecules supplier, chemical structure Endosidin 2 | Exocytosis & endosomal recycling inhibitor | CAS 1839524-44-5
    $50.00
    Endosidin-2 (1839524-44-5) binds to the EXO70 subunit of the exocyst complex which results in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking...

  • Focus Biomolecules supplier, chemical structure of Exo2 | GBF1 inhibitor - induces Golgi disassembly | CAS 304684-77-3
    $62.00
    Exo2 (304684-77-3) disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells.1 May be used to completely ablate the Golgi apparatus.1 Like brefeldin A (BFA), it inhibits anterograde transport and...

  • Focus Biomolecules supplier, chemical structure of Fatostatin | SREBP activation inhibitor | CAS 125256-00-0
    $50.00
    Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FLI-06 | Notch pathway inhibitor | CAS 313967-18-9
    $80.00
    FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from...

  • Focus Biomolecules supplier, chemical structure of Importazole | Blocks importin-β-mediated nuclear import | CAS 662163-81-7
    $50.00
    Importazole (662163-81-7) specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export.1 When added to cells during mitosis,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of LDN-57444 | DUB inhibitor | CAS 668467-91-2
    $90.00
    LDN-57444 (668467-91-2) inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. LDN-57444 causes dramatic alterations...

  • Focus Biomolecules supplier, chemical structure of Leptomycin B | Nuclear export inhibitor | CAS 87081-35-4
    $60.00
    Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-11. Inhibits the nuclear export of the HIV regulatory protein Rev2. Leptomycin B stabilizes...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MiTMAB | Dynamin inhibitor | CAS 1119-97-7
    $55.00
    MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ML-SA1 | TRPML activator | CAS 332382-54-4
    $75.00
    ML-SA1 (332382-54-4) is a TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Nocodazole | Microtubule inhibitor | CAS 31430-18-9
    $50.00
    Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi...

  • Focus Biomolecules supplier, structure of Prostaglandin E2 | PGE2 | Prostaglandin E (EP) receptor agonist | CAS 363-24-6
    $25.00
    Prostaglandin E2 (363-24-6; PGE2) is an endogenous prostaglandin derived from the action of cyclooxygenase on arachidonic acid. PGE2 has diverse biological actions in the areas of inflammation, cancer, immune modulation,...

  • Focus Biomolecules reagent supplier, chemical structure of Salubrinal | eIF2a Phosphatase inhibitor | CAS 405060-95-9
    $80.00
    Salubrinal (405060-95-9) is an endoplasmic reticulum (ER) stress inhibitor. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-083010 | IRE1 inhibitor | CAS 307543-71-1
    $45.00
    STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8
    $58.00
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

  • Focus Biomolecules, Tyrphostin 9 structure | PDGFR kinase inhibitor & Oxidative phosphorylation inhibitor | CAS 10537-47-0
    $30.00
    Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50 = 1.2 μM)1 and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria3. Tyrphostin 9 perturbs...

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