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  • Focus Biomolecules cell signaling reagent supplier, Brefeldin A | Inhibits intracellular transport | CAS 20350-15-6
    Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable. References/Citations1)...

  • Focus Biomolecules, chemical structure CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase | CAS 166981-13-1
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • Focus Biomolecules supplier, chemical structure of Exo2 | GBF1 inhibitor - induces Golgi disassembly | CAS 304684-77-3
    Exo2 (304684-77-3) disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells.1 May be used to completely ablate the Golgi apparatus.1 Like brefeldin A (BFA), it inhibits anterograde transport and...

  • Focus Biomolecules supplier, chemical structure of Fatostatin | SREBP activation inhibitor | CAS 125256-00-0
    Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FLI-06 | Notch pathway inhibitor | CAS 313967-18-9
    FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of LDN-57444 | DUB inhibitor | CAS 668467-91-2
    LDN-57444 (668467-91-2) inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. LDN-57444 causes dramatic alterations...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Nocodazole | Microtubule inhibitor | CAS 31430-18-9
    Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi...

  • Focus Biomolecules reagent supplier, chemical structure of Salubrinal | eIF2a Phosphatase inhibitor | CAS 405060-95-9
    Salubrinal (405060-95-9) is an endoplasmic reticulum (ER) stress inhibitor. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-083010 | IRE1 inhibitor | CAS 307543-71-1
    STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

  • Focus Biomolecules, Tyrphostin 9 structure | PDGFR kinase inhibitor & Oxidative phosphorylation inhibitor | CAS 10537-47-0
    Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50 = 1.2 μM)1 and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria3. Tyrphostin 9 perturbs...

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