Prochlorperazine maleate | Endocytosis inhibitor

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5.

References/Citations
1) Daniel et al. (2015), Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic, 16 635
2) Chew et al. (2020), Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell, 180 895
3) Hollister et al. (1969), Clinical use of psychotherapeutic drugs: current status; Clin. Pharmacol. Ther., 10 170
4) Cook and Newberry (2018), Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J., 40 148
5) Van den Berg et al. (1996), The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care, 24 538

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

100 mg, 500 mg

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CAS:
84-02-6
Catalog Number:
10-3474
Activity:
Endocytosis inhibitor
Chemical Name:
2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate
Molecular Weight:
606.09
Molecular Formula:
C20H24ClN3S • 2C4H4O4
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Prochlorperazine maleate | Endocytosis inhibitor

$180.00$550.00

CAS:
84-02-6
Catalog Number:
10-3474
Activity:
Endocytosis inhibitor
Chemical Name:
2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate
Molecular Weight:
606.09
Molecular Formula:
C20H24ClN3S • 2C4H4O4
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 100 mg
  • 500 mg
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