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17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand

Catalog Number:
10-1577
Activity:
Geldanamycin affinity chromatography ligand
Chemical Name:
17-(6-Aminohexylamino)-17-demethoxygeldanamycin
Alternate Names:
AH-GDM
Molecular Weight:
644.80
Molecular Formula:
C34H52N4O8
Solubility:
Soluble in DMSO (up to at least 50 mg/ml)
Physical Properties:
Dark red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity columns for purification of HSP90 and associated client proteins.1,2 Has been used in a copolymeric composition for geldanamycin sustained delivery and controlled release3,4 as well as other applications.

References/Citations:

1) Xie et al. (2005), Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion; Oncogene, 24 3697
2) Marcu et al. (2000), Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins; J. Natl. Cancer Inst., 92 242
3) Borgman et al. (2009), Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery; Mol. Pharmacol. 6 1836
4) Kasuya et al. (2001), Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates; J. Control. Release, 74 203

17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand is also available in the Cellular Metabolism Library.
Catalog Number:
10-1577
Activity:
Geldanamycin affinity chromatography ligand
Chemical Name:
17-(6-Aminohexylamino)-17-demethoxygeldanamycin
Alternate Names:
AH-GDM
Molecular Weight:
644.80
Molecular Formula:
C34H52N4O8
Solubility:
Soluble in DMSO (up to at least 50 mg/ml)
Physical Properties:
Dark red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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