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17-DMAG | HSP90 inhibitor

17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable.

References/Citations:

1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637
2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

1 mg, 5 mg

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CAS:
150270-08-9
Catalog Number:
10-1169
Activity:
HSP90 inhibitor
Alternate Names:
NSC 707545
Chemical Name:
17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin
Alternate Name:
Alvespimycin
Molecular Weight:
616.763
Molecular Formula:
C32H48N4O8
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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17-DMAG | HSP90 inhibitor

$32.00 – $80.00

CAS:
150270-08-9
Catalog Number:
10-1169
Activity:
HSP90 inhibitor
Alternate Names:
NSC 707545
Chemical Name:
17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin
Alternate Name:
Alvespimycin
Molecular Weight:
616.763
Molecular Formula:
C32H48N4O8
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 1 mg
  • 5 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

SKU: 10-1169 Categories: , , , , , , , , , Tags: , , , , ,
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