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17-GMP-APA-GA | Modified Geldanamycin

17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.

References/Citations:

1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460
2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786
3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

1 mg, 5 mg

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CAS:
not available
Catalog Number:
10-1324
Activity:
Modified Geldanamycin
Chemical Name:
17-(3-(4-Maleimidobutylcarboxamido)propropylamino)-demethoxygeldanamycin
Molecular Weight:
767.89
Molecular Formula:
C39H53N5O11
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be made fresh and used within 1 working day.
Shipping Code:
RT

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17-GMP-APA-GA | Modified Geldanamycin

$140.00 – $500.00

CAS:
not available
Catalog Number:
10-1324
Activity:
Modified Geldanamycin
Chemical Name:
17-(3-(4-Maleimidobutylcarboxamido)propropylamino)-demethoxygeldanamycin
Molecular Weight:
767.89
Molecular Formula:
C39H53N5O11
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be made fresh and used within 1 working day.
Shipping Code:
RT
  • 1 mg
  • 5 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

SKU: 10-1324 Categories: , , , , , , , Tags: , ,
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