BiochemicalTargets

Sigma receptor

Sigma receptors, originally thought to be a type of opioid receptor, are non-GPCR transmembrane proteins expressed mainly in the endoplasmic reticulum and associated with the mitochondria. There are two receptor subtypes, σ1 and σ2, that act as chaperone proteins that modulate several physiological pathways involved in Er stress and Ca2+ homeostasis. Modulators of these receptors have been shown to have neuroprotective, antiproliferative, and antinociceptive effects.

Antagonists

BD1047 dihydrobromide | Selective sigma-1 antagonist

CAS:
138356-21-5
Catalog Number:
10-4210
Activity:
Selective sigma-1 antagonist
Chemical Name:
N-[2-(3,4Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
Molecular Weight:
437.04
Molecular Formula:
C13H20Cl2N2 • 2HBr
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

BD1063 dihydrochloride | Selective sigma-1 antagonist

CAS:
206996-13-6
Catalog Number:
10-4211
Activity:
Selective sigma-1 antagonist
Chemical Name:
1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride
Molecular Weight:
346.13
Molecular Formula:
C13H18Cl2N2 • 2HCl
Solubility:
Soluble in Water (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

NE-100 | Selective sigma-1 antagonist

CAS:
149409-57-4
Catalog Number:
10-4200
Activity:
Selective sigma-1 antagonist
Chemical Name:
4-Methoxy-3-(2-phenylethoxy)-N,N,dipropylbenzeneethanamine hydrochloride
Molecular Weight:
391.97
Molecular Formula:
C23H33NO2 • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT