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Cholesterol

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  • 20(S)-Hydroxycholesterol | Smoothened activator
    20(S)-Hydroxycholesterol | Smoothened activator
    $45.00
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

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  • Focus Biomolecules cell signaling reagent supplier, structure of 24(S),25-Epoxycholesterol | LXR agonist | CAS 77058-74-3
    24(S),25-Epoxycholesterol | LXR agonist
    $150.00
    24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular cholesterol homeostasis.2 24(S),25-Epoxycholesterol promotes neural...

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  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
    $50.00
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

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  • 25-Hydroxycholesterol | Biologically active cholesterol metabolite
    25-Hydroxycholesterol | Biologically active cholesterol metabolite
    $19.00
    25 Hydroxycholesterol (2140-46-7) is a metabolite resulting from the action of cholesterol 25-hydroxylase on cholesterol. However, since cholesterol 25-hydroxylase knock-out mice still have significant levels of...

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  • 27-Hydroxycholesterol | Cholesterol oxidation metabolite
    27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

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  • 5alpha,6alpha-Epoxycholesterol | LXR ligand
    5alpha,6alpha-Epoxycholesterol | LXR ligand
    $25.00
    5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol.  It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3...

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  • Filipin III | 480-49-9 | Structure | Supplier
    Filipin III | Cholesterol probe
    $120.00
    Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used...

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  • Fluvastatin Na | HMG CoA reductase inhibitor
    Fluvastatin Na | HMG CoA reductase inhibitor
    $30.00
    Potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1  Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2 Displays antineuroinflammatory...

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  • Hymeglusin | Melvalonate biosynthesis inhibitor
    Hymeglusin | Melvalonate biosynthesis inhibitor
    $200.00
    Hymeglusin (29066-42-0) is a inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 mM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis...

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  • Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    Itraconazole | Autophagy inducer / Inhibits glioblastoma growth
    $40.00
    Itraconazole (84625-61-6) inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme.1 Clinically useful antifungal agent. It inhibits the proliferation of...

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  • Focus Biomolecules cell signaling reagent supplier, structure Lovastatin | HMG-CoA reductase inhibitor | CAS 75330-75-5
    Lovastatin | HMG-CoA reductase inhibitor
    $41.00
    Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4...

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  • Focus Biomolecules supplier, chemical structure of RVX-208 | BET bromodomain inhibitor | CAS 1044870-39-4
    RVX-208 | BET bromodomain inhibitor
    $68.00
    RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD11,2. RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in...

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  • Focus Biomolecules cell signaling reagent supplier, structure Simvastatin | HMG-CoA reductase inhibitor | CAS 79902-63-9
    Simvastatin | HMG-CoA reductase inhibitor
    $30.00
    Simvastatin (79902-63-9) is a synthetic analog of lovastatin (cat.# 10-1222). Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase1,2. Simvastatin induces apoptosis in various cell lines and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TMP-153 | ACAT inhibitor | CAS 128831-46-9
    TMP-153 | ACAT inhibitor
    $36.00
    TMP-153 (128831-46-9) is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.1,2 TMP-153...

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  • Focus Biomolecules cell signaling reagent supplier, structure U-18666A | Cholesterol transport inhibitor | CAS 3039-71-2
    U-18666A | Cholesterol transport inhibitor
    $80.00
    U-18666A (3039-71-2) is an oxidosqualene reductase inhibitor.1 Inhibits the egress of cholesterol from late endosomes and lysosomes.2 U-18666A is also used to study Niemann-Pick disease and for assessing the importance of...

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