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7α-Hydroxycholesterol | Bile acid precursor

CAS:
566-26-7
Catalog Number:
10-4538
Activity:
Bile acid precursor
Chemical Name:
5-Cholesten-3β, 7α-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO or in Ethanol.
Physical Properties:
White or pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

7α-Hydroxycholesterol (566-26-7) is a metabolite resulting from the action of cholesterol 7α-hydroxylase on cholesterol. 7α-Hydroxycholesterol is the first intermediate and a rate limiting step in the major pathway for bile acid synthesis in humans.  A pro-inflammatory mediator which upregulates production of CCL2 and MMP9 in macrophages and may promote progression of atherosclerosis.2,3 Possible biomarker for cellular lipid peroxidation.4

References/Citations:

1) Duane and Javitt (2002), Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?; J. Lab. Clin. Med., 139 109
2) Kim et al. (2015) 7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2; Biochem. Biophys. Res. Commun., 467 879
3) Kim et al. (2014) 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes; Toxicol. Appl. Pharmacol., 274 462
4) Saito and Noguchi (2014) 7-Hydroxycholesterol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation; Biochem. Biophys. Res. Commun., 446 741

7α-Hydroxycholesterol | Bile acid precursor is also available in the Cellular Metabolism Library.
CAS:
566-26-7
Catalog Number:
10-4538
Activity:
Bile acid precursor
Chemical Name:
5-Cholesten-3β, 7α-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO or in Ethanol.
Physical Properties:
White or pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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