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Biosynthesis Inhibition

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AK-7 | SIRT2 inhibitor | CAS 420831-40-9
    $50.00
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

  • Focus Biomolecules cell signaling supplier, chemical structure Fluvastatin Na | HMG CoA reductase inhibitor | CAS 93957-55-2
    $30.00
    Fluvastatin Na (CAS 93957-55-2) is a potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1  Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2...

  • Focus Biomolecules reagent supplier, chemical structure of Hymeglusin | Melvalonate biosynthesis inhibitor | CAS 29066-42-0
    $200.00
    Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol...

  • Focus Biomolecules, chemical structure Itraconazole | Autophagy inducer / Inhibits glioblastoma growth | CAS 84625-61-6
    $40.00
    Itraconazole (84625-61-6) inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme.1 Clinically useful antifungal agent. It inhibits the proliferation of...

  • Focus Biomolecules cell signaling reagent supplier, structure Lovastatin | HMG-CoA reductase inhibitor | CAS 75330-75-5
    $50.00
    Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4...

  • Focus Biomolecules cell signaling reagent supplier, structure Simvastatin | HMG-CoA reductase inhibitor | CAS 79902-63-9
    $50.00
    Simvastatin (79902-63-9) is a synthetic analog of lovastatin (cat.# 10-1222). Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase1,2. Simvastatin induces apoptosis in various cell lines and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TMP-153 | ACAT inhibitor | CAS 128831-46-9
    $36.00
    TMP-153 (128831-46-9) is a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), IC50=5-10 nM. It inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.1,2 TMP-153...

  • Focus Biomolecules cell signaling reagent supplier, structure U-18666A | Cholesterol transport inhibitor | CAS 3039-71-2
    $80.00
    U-18666A (3039-71-2) is an oxidosqualene reductase inhibitor.1 Inhibits the egress of cholesterol from late endosomes and lysosomes.2 U-18666A is also used to study Niemann-Pick disease and for assessing the importance of...

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