NLRP3i | NLRP3 Inflammasome inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $130.00 |
NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2
References/Citations:
1) Fulp et al. (2018), Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem., 61 5412
2) Marchetti et al. (2014), A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol., 63 316
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2
References/Citations:
1) Fulp et al. (2018), Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem., 61 5412
2) Marchetti et al. (2014), A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol., 63 316
Related products
-
Ro 13-6438 | PDE3 inhibitor
From $75.00CAS:70018-51-8Catalog Number:10-1056Activity:PDE3 inhibitorChemical Name:(R)-6-Chloro-1,5-dihydro-3-methylimidazo[2,1-b]quinazolin-2-oneMolecular Weight:235.67Molecular Formula:C11H10ClN3Solubility:Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 1 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 monthsShipping Code:RT -
Simvastatin | HMG-CoA reductase inhibitor
From $50.00CAS:79902-63-9Catalog Number:10-1018Activity:HMG-CoA reductase inhibitorAlternate Names:MevinolinChemical Name:2,2-Dimethyl-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acidMolecular Weight:418.58Molecular Formula:C25H38O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Isradipine | L-type Ca channel blocker
From $64.00CAS:75695-93-1Catalog Number:10-1202Activity:L-type Ca channel blockerChemical Name:4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, methyl, 1-methylethyl diesterMolecular Weight:371.4Molecular Formula:C19H21N3O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).Physical Properties:Yellow solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.