KL044 | Cryptochrome stabilizer
KL044 (1801856-93-8) is a potent stabilizer of the circadian clock protein cryptochrome (CRY).1 It lengthened the circadian period and repressed Per2 activity in reporter assays with 10-fold more potency
Circadian Clock
Cells and organisms are subject to a cyclical process known as the circadian clock or rhythm that repeats roughly every 24 hours. It regulates processes such as sleep, metabolism, and immune and endocrine function, and is controlled by both internal (cellular electrical activity) and external factors (such as light and temperature). It has major influence on diseases such as cancer, obesity, and diabetes.
Cryptochrome
KL101 | Selective circadian clock protein CRY1 stabilizer
CAS:
396721-89-4
Catalog Number:
10-3907
Activity:
Selective circadian clock protein CRY1 stabilizer
Chemical Name:
N-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethylbenzamide
Molecular Weight:
377.51
Molecular Formula:
C22H23N3OS
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
TH301 | Selective circadian clock protein CRY2 stabilizer
CAS:
450338-32-6
Catalog Number:
10-3909
Activity:
Selective circadian clock protein CRY2 stabilizer
Chemical Name:
1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide
Molecular Weight:
485.98
Molecular Formula:
C24H24ClN3O4S
Solubility:
Soluble in DMSO
Physical Properties:
Waxy orange solid
Purity:
>98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Kinases
PF-670462 dihydrochloride | Casein kinase 1δ/ε inhibitor
PF-670462 (950912-80-8) is a potent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust
GO289 | CK2 inhibitor
CAS:
694522-87-7
Catalog Number:
10-4678
Activity:
CK2 inhibitor
Chemical Names:
(E)-5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-4-yl)imino)methyl)phenol
Molecular Weight:
419.30
Molecular Formula:
C17H15BrN4O2S
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
LH-846 | Casein kinase 1 delta inhibitor
CAS:
639052-78-1
Catalog Number:
10-1465
Activity:
Casein kinase 1 delta inhibitor
Chemical Name:
N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneaceramide
Molecular Weight:
316.81
Molecular Formula:
C16H13ClN2OS
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
REV-ERB
GSK4112 | Rev-Erbα agonist
CAS:
1216744-19-2
Catalog Number:
10-5493
Activity:
Rev-Erbα agonist
Chemical Names:
N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester
Alternate Name:
SR6452
Molecular Weight:
396.89
Molecular Formula:
C18H21ClN2O4S
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
SR-8278 | REV-ERBα antagonist
CAS:
125944-66-5
Catalog Number:
10-1506
Activity:
REV-ERBα antagonist
Chemical Name:
1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Molecular Weight:
361.49
Molecular Formula:
C18H19NO3S2
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White waxy solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
SR-9009 | RevErb alpha/beta agonist
CAS:
1379686-30-2
Catalog Number:
10-1511
Activity:
RevErbα/β agonist
Chemical Name:
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Molecular Weight:
474.4
Molecular Formula:
C20H24CLN3O4S HCl
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
ROR
SR1078 | ROR agonist
SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian
Nobiletin | Attenuates metabolic syndrome
CAS:
478-01-3
Catalog Number:
10-4763
Activity:
Attenuates metabolic syndrome
Chemical Name:
3’,4’,5,6,7,8-Hexamethoxyflavone
Molecular Weight:
402.39
Molecular Formula:
C21H22O8
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
SR1001 | RORα gamma inverse agonist
CAS:
1335106-03-0
Catalog Number:
10-1290
Activity:
RORα inverse agonist
Chemical Name:
N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
Molecular Weight:
477.39
Molecular Formula:
C15H13F6N6O4S2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Physical Properties:
Pale beige solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Other Circadian Clock
SRT1720 HCl | SIRT1 activator
CAS:
1001645-58-4
Catalog Number:
10-4628
Activity:
SIRT1 activator
Chemical Names:
N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide hydrochloride; SIRT 1933
Molecular Weight:
506.02
Molecular Formula:
C25H23N7OS·HCl
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
AE 51310 | OPN4/melanopsin antagonist
CAS:
433966-92-8
Catalog Number:
10-4655
Activity:
OPN4/melanopsin antagonist
Chemical Names:
1-(2,5-Dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine
Molecular Weight:
338.24
Molecular Formula:
C14H17Cl2NO3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Lycorine HCl | Protein synthesis inhibitor/SCAP degrader
CAS:
2188-68-3
Catalog Number:
10-2608
Activity:
Protein synthesis inhibitor/SCAP degrader
Chemical Names:
Galanthidine; Amarylline; Narcissine
Molecular Weight:
323.77
Molecular Formula:
C16H17NO4·HCl
Solubility:
Soluble in water (15 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
